A266 HEPATOCELLULAR CARCINOMA PREVALENCE IN NON-CIRRHOTIC HEPATITIS C PATIENTS
Notice bibliographique
Résumé
According to WHO, HCC is the fifth most common tumor in men worldwide and the second most common cause of cancer related death. In adult women, it is the seventh most commonly diagnosed cancer and the sixth leading cause of cancer death. 1 Almost 80 percent of cases are due to underlying chronic hepatitis B and C virus infection. Previous studies showed incidence of HCC in non-cirrhotic HCV patients was ranging between 4.4–10.6 %. According to WHO, HCC is the fifth most common tumor in men worldwide and the second most common cause of cancer related death. In adult women, it is the seventh most commonly diagnosed cancer and the sixth leading cause of cancer death. 1 Almost 80 percent of cases are due to underlying chronic hepatitis B and C virus infection. Previous studies showed incidence of HCC in non-cirrhotic HCV patients was ranging between 4.4–10.6 %. The aim of our analysis is to determine the prevalence of HCC among liver transplant patients with hepatitis C virus in the absence of histologic cirrhosis. Secondary outcomes are to determine the characteristics of those patients and other possible contributing etiologies to developing HCC in the absence of cirrhosis We did a retrospective charts review of transplant patients in our center. We included all HCV patients who had HCC pre-liver transplant and excluded all patients younger than 18 or with other causes of cirrhosis. We reviewed the pathology reports of all explants to determine the fibrosis stage. We included 98 hepatitis C patients in our analysis. 91.1% were males with the mean age of the patients of 57.1 +/- 10 years. 99% of the patients were having a viral load of > 3 x 10/6 U/L. The most common HCV genotype was 1 (68%). Alcohol was the most common cofactor contributing to cirrhosis. Two patients (2%) were found to have fibrosis stage 2 and 3. First patient was a 50-years-old male with HCV infection (unknown genotype and viral load) and alcoholic hepatitis history and no other co-morbidities. His MELD and MELD-Na scores were 7 and 13, respectively. He had multi-focal HCC on both US and histopathology of the explant with a total tumor volume (TTV) of 45 and no lympho-vascular invasion. His fibrosis stage was F3. Second patient was a 65-years-old male with HCV infection genotype 1A and a pre-transplant viral load of 7.2 x 105. His BMI was 27.2. He had OSA being treated with C-PAP. His MELD and MELD-Na were 7 and 19. His multi-focal HCC and his TTV was 26. He underwent TACE pre-transplantation. He had no lympho-vascular invasion. His fibrosis stage was F2. Regression analysis of the factors contributing to this showed no significant correlation. Rate of HCC in non-cirrhotic HCV is still within the rate of previously reported studies. Although larger study including non-transplanted patients may revel higher incidence. None
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,002 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,002 | 0,002 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,005 | 0,001 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».