A40 INCIDENCE, CLINICAL FEATURES, AND INVESTIGATION OF ACHALASIA IN NEWFOUNDLAND AND LABRADOR
Notice bibliographique
Résumé
Achalasia is a rare esophageal motility disorder of unknown etiology. Patients commonly present with dysphagia, regurgitation and weight loss. Previous epidemiologic studies have suggested an equal male to female ratio and adult onset. Incidence rates range between 0.29 – 1.63/ 100,000 per year. Endoscopic and esophagram findings are often abnormal, however, manometry is required to diagnose achalasia. This 11-year retrospective study outlines incidence, clinical features, and describes diagnostic findings in incident cases of achalasia in Newfoundland and Labrador. Patient charts with ICD codes indicating a diagnosis of achalasia between 2005 and 2015 were retrieved from medical records. Charts with a diagnosis of achalasia by manometry prior to 2005 were not reviewed. Patients diagnosed with achalasia based on endoscopy or imaging prior to 2005 were included if their initial diagnostic manometry occurred between 2005 and 2015. The date of diagnosis was recorded as the date of official diagnostic manometry. Epidemiologic data, manometry, endoscopy and esophagram findings were compiled by chart review. 73 cases of achalasia were diagnosed with manometry between 2005 and 2015 in Newfoundland and Labrador. The average age at diagnosis was 52. Males represented 60% of cases. The midpoint incidence of achalasia was 1.42/100,000. Dysphagia occurred in 97% of patients, regurgitation in 73%, weight loss in 71%, chest pain in 22%, and aspiration in 11%. Upper endoscopy was abnormal in 81% of patients. The most common endoscopic finding was narrowing of the gastroesophageal junction followed by dilatation of the esophageal body. Abnormal barium esophagram occurred in 74.0%. An abnormal GEJ was the most common finding on barium esophagram, seen in 64%, followed by esophageal dilatation in 41%. Abnormal manometry was a key feature in all patients. The incidence of achalasia in Newfoundland is similar to the incidence reported by a similar study in Alberta, although higher than reported by studies in Singapore and Iceland. Age and sex distribution is similar to findings in previous studies. Upper endoscopy and barium esophagram were frequently, but not exclusively, abnormal. There were several limitations to the present study, including suspected cases that were treated without referral for manometry, and lack of access to endoscopy and esophagram records. None
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,002 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,002 | 0,002 |
| Études des sciences et des technologies | 0,001 | 0,001 |
| Communication savante | 0,001 | 0,000 |
| Science ouverte | 0,001 | 0,001 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,001 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».