A196 AN EXTRA BENEFIT TO USING STATINS: A CLINICAL OBSERVATIONAL STUDY ON NAFLD PATIENTS (PILOT STUDY)
Notice bibliographique
Résumé
Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide – with an estimated 25% of Canadians affected. NAFLD has the potential to progress to nonalcoholic steatohepatitis (NASH), cirrhosis and fibrosis of the liver, and ultimately, liver failure. Globally, cirrhosis affects 1.6% people. NAFLD is often asymptomatic and found in people with metabolic syndrome. Both conditions can progress to an adverse event which relies on antidyslipidemic agents for treatment. The first-line of treatment for patients with dyslipidemia are statins. Recently, the use of statins has been suggested to be safe in NAFLD patients, but there is a lack in certainty of its effectivity in treating liver disease. To determine if statins are effective for NAFLD treatment. An observational study was conducted at the NorthGate Clinic, by searching for patients undergoing statin treatment with NAFLD suppression. A FibroScore was obtained for the patients to establish the severity of liver damage and NAFLD. Patients were then retested to obtain a post-stain use FibroScore. Alanine transaminase (ALT) and aspartate transaminase (AST) levels, another measure of liver condition, were also assessed with the continued usage of statins. After determining the cases with NAFLD, these cases were then included based on their improvement post-statin usage. A total of 27 patients from the NorthGate Clinic met the inclusion criteria. These NAFLD patients were on statins to treat some form of dyslipidemia, and found an additional benefit of the drug – suppression of the symptoms of and treatment of NAFLD. However, only 21 patients had pre- and post-FibroScore data. Overall, patients found a decrease in FibroScore, ALT and AST levels with the continued usage of statins. Evidence from the observational study indicated that the use of statins was associated with the suppression of NAFLD symptoms and a lower FibroScore, and ALT and AST levels. In general, this study suggests that the usage of statins was beneficial and safe in a particular sub-segment of the Canadian population with NAFLD. Therefore, suggesting that NAFLD patients are a population of interest. Limitations of the observational study included insufficient statistical power, uncontrolled selection bias and confounding factors. Moreover, since the data was obtained retrospectively, some data was missing. Thus, this study cannot assert that usage of statins induced an improvement to the liver (lower AST and ALT levels, and FibroScore). Currently, available studies indicate that the benefits of statins outweigh the adverse effects of these drugs in NAFLD patients. Additional research needs to be provided on the long-term side effects associated with the use of statins in this population. Future studies should focus on providing more evidence to support the effect of statins in NAFLD patients. None
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,007 | 0,004 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,001 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,001 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».