A16 FOLLOWING AN ANTI-INFLAMMATORY DIET PREVENTS INCREASES OF FECAL CALPROTECTIN AND ALTERS METABOLOMIC PROFILE OF ULCERATIVE COLITIS PATIENTS, A RANDOMIZED CONTROLLED TRIAL
Notice bibliographique
Résumé
A relationship between ulcerative colitis and diet has been shown in epidemiological and experimental studies. To investigate the effectiveness of an anti-inflammatory diet for maintenance of remission in UC patients. In this 6-month randomized control trial, adult UC patients in clinical remission (partial Mayo score<3) who had a disease relapse within the previous 18 months were randomized to either an “Anti-inflammatory Diet (AID)” or “Canada’s Food Guide (CFG)” as the control group.A dietitian provided dietary recommendations to all patients in four face-to-face (baseline, month 1, 3, and 6) and three telephone (month 2,4,5) sessions. Menu plans provided to patients in the AID group were designed to increase dietary intake of fiber, prebiotics, probiotics, anti-oxidants, omega-3 fatty acids and to decrease dietary intake of red or processed meat, added sugar and alcohol. To assess clinical relapse, partial Mayo scoring was done monthly. Monthly 24h dietary recalls were used to assess adherence to the diets. At baseline and month 6 or relapse, fecal calprotectin (FCP), serum CRP, and quality of life were assessed. Metabolomic analysis was performed on urine (GC-MS, DI- LC MS/MS), serum (NMR, DI-LC MS/MS) and stool (NMR) samples collected at baseline and month 6 or relapse. Fifty-three patients were randomized to the two diet groups. The mean age of participants was 41.4 ± 14.7 y and 34 (64.2%) subjects were female. Five(19.2%) patients in the AID and 8(29.6%) patients in the control group relapsed during the trial (P=0.38). Patients following CFG had a statistically significant increase in FCP from baseline to month6/relapse, while patients following the AID showed no significant increase in their FCP over the 6 months (Figure1A). At baseline, the metabolomic profiles of patients randomized to the two groups were similar. However, at 6 months/relapse, the two groups had separated (Figure1B). In comparison to CFG group, patients in the AID group had higher glutamic acid(stool), creatinine (stool), and carnosine (urine) but lower 3-(3-hydroxyphenyl)-3-hydroxypropionic acid (urine), hydroxymandelic acid (urine), phosphatidylcholines (serum), acetone (stool), and Sumiki’s acid (urine). In comparison to the CFG group, patients in the AID group had a significant increase in dietary intake of some nutrients including zinc, selenium and phosphorus from baseline to month 6 or relapse. Modification of diet towards an inclusion of anti-inflammatory and reduction of inflammatory foods alters host and microbial metabolic pathways and can help prevent increases in colonic inflammation in UC patients in remission. Figure 1.A) Comparison of changes in fecal calprotectin levels from baseline to month 6/relapse between the two diet groups;B) Partial least squares discriminant analysis plot showing a significant difference in the metabolome of patients randomized to the two diet groups at month 6/relapse as identified by metabolites in urine,serum and fecal samples. Alberta Innovates Health Solutions
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,002 |
| Méta-épidémiologie (sens strict) | 0,002 | 0,001 |
| Méta-épidémiologie (sens large) | 0,004 | 0,003 |
| Bibliométrie | 0,001 | 0,001 |
| Études des sciences et des technologies | 0,001 | 0,001 |
| Communication savante | 0,001 | 0,001 |
| Science ouverte | 0,001 | 0,000 |
| Intégrité de la recherche | 0,003 | 0,002 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,009 | 0,001 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».