P343 Levels of the anticoagulant and anti-inflammatory protein S (PROS1) in patients with inflammatory bowel disease (IBD) relationship with disease activity, IBD disease patterns, and C4-binding protein (C4BP)
Notice bibliographique
Résumé
Inflammatory bowel diseases (IBD), ulcerative colitis (UC) and Crohn’s disease (CD) show an increased risk of thrombosis. PROS1 is a well-established anticoagulant. Plasma PROS1 circulates in a free form that can function as an anticoagulant or in complex with the complement C4b-binding protein (C4BP). Interestingly, PROS1 has also emerged as a potent anti-inflammatory mediator due to its function as agonist of the TAM receptor tyrosine kinases (Rothlin 2015). Here, we aimed to test if IBD or subsets of IBD are associated with reduced amounts of the anticoagulant and anti-inflammatory protein, PROS1. AIMS: to measure and compare free PROS1 and total C4BP levels in CD, UC and healthy controls and their relationship with activity status (Determined for indexes: CDAI, Mayo) and disease patterns (Montreal). Free PROS1 and C4BP (immunoturburbimetry, Liatest, Stago, France) were determined in 103 IBD patients (45 M, 58 F, UC: n = 66, CD n = 37) and 30 healthy controls (18 M, 12 F), mean ages: 37.5 ± 15.6, 41.4 ± 14.6, 38.2 ± 12.2, respectively. Mean PROS1 levels in CD (89.9. ± 28.0) were significantly lower compared with controls (109.6 ± 23.9, p = 0.0019) and UC (104.4 ± 27.0, p = 0.0076). Within the CD group, a statistical difference vs. controls was observed in patients with active disease (n = 25, levels 84.9 ± 24.1, p = 0.0004), but not in patients in remission (n = 12: 100.2 ± 33.5). Moreover, the moderate–severe subset (n = 21), presented the lowest levels (84.0 ± 25.9) vs. controls p = 0.0006. In UC, PROS1 levels did not show differences between subsets (42 active, 24 remission: 101.1 ± 26.3 and 110.0 ± 27, respectively) or with controls. CD patterns (behaviour, location) and UC extent (12 proctitis, 54 more extensive) did not show significant differences. C4BP levels were also found to be decreased in CD (global sample, active patients, severe-moderate subsets: 98.6 ± 14.4, 98.8 ± 12.0, 98.4 ± 12.6, 109.9 ± 8.8, p = 0.0004, p = 0.0008, p = 0.0014 vs. controls, respectively). Unlike PROS1, C4BP in UC (102.8 ± 9.9) was lower than in controls (p = 0.0010) mainly in severe–moderate activity (p = 0.0322), and besides, no statistical differences were observed between UC and CD. (1) Free PROS1 levels were significantly lower in active CD vs. controls (especially in the severe–moderate activity subsets), but in the case of UC the levels were indistinguishable from controls. On contrary, C4BP levels were reduced in both diseases, particularly in patients with higher disease activity. (2) Decrease of Free PROS1 in CD, was not secondary to a potential C4BP-bound PROS1 for C4BP increase. (3) Future studies will aim to test if reduced levels of PROS1 in circulation might not only contribute to the increased risk of thrombosis but also to the enhanced inflammation in CD.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,001 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,002 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».