A314 A CHARACTERIZATION OF NUTRITION STATUS AND GUT MICROBIOTA IN OBSESSIVE-COMPULSIVE DISORDER (OCD) IN YOUTH
Notice bibliographique
Résumé
Obsessive compulsive disorder (OCD) affects ~5.2–10.4 million North Americans. Most commonly diagnosed in childhood and adolescence, it can result in years of struggle and has been listed among the top ten causes of disability by the World Health Organization. Zinc is physiologically essential and integral for optimal health; however, zinc deficiency is quite prevalent. Not only are youth (particularly females) more likely to have zinc deficiency risk factors, but they are also in a life stage where zinc deficiency is more problematic, based on its importance developmentally. Neural zinc levels have implications for neuroplasticity (a factor in cognitive flexibility, a feature of executive function that is impaired in OCD). Additionally, zinc supplementation has been demonstrated to improve mental health, and in animal models, zinc deficiency has been shown to alter the gut microbiota. Gut microbiota profiles have been linked to anxiety and depression (potentially due to interactions with the enteric nervous system). Given the high co-occurrence rates between these and OCD, as well as the fact that patients with OCD have been reported to have higher rates of gastrointestinal distress than controls, an investigation into nutrition and gut microbiota profiles in youth with OCD is a logical step. The aim of this study was to assess the role of zinc and of the gut microbiota in OCD in youth, and to determine any differences between youth with and without OCD. It was hypothesized that higher zinc intake and status, as well as greater gut microbial diversity, would be associated with greater cognitive flexibility and with decreased OCD symptom severity. It was also thought that youth with OCD would be more likely to have non-optimal nutrient intake/levels and dysregulation of gut microbiota than youth without OCD. Zinc status analysis was conducted via 3-day dietary record, serum levels, and hair levels. Berg’s Card-Sorting Test and Trail-Making Tests A&B were used to assess cognitive flexibility; clinical interview and self-report scales measured anxiety, depression, and OCD symptoms; and gut microbiota was quantified via stool samples analyzed using qPCR and 16S sequencing. Data were compared for youth with OCD versus youth without OCD. Commonalities among dietary intake patterns and nutrient status for youth with OCD, as well as their gut microbiota profiles in comparison to youth without OCD, will be discussed. Nutritional status’ impact on mental health is underexplored, and no literature to date combines analysis of zinc, cognitive flexibility, and gut microbiota, particularly in OCD. This study’s characterization of nutrient intake/status and gut microbiota has the potential to aid development of alternative therapies for youth with OCD. Ferring Canada, Branch-Out Neurological Foundation, Mathison Centre for Mental Health Research & Education
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Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».