A284 CHARACTERIZING SIMULTANEOUS PRESSURE WAVES IN THE HUMAN COLON BY HIGH-RESOLUTION MANOMETRY
Notice bibliographique
Résumé
High-resolution colonic manometry promises much deeper insight into human colon motor function and their control mechanisms than hitherto possible. One motor pattern in need of full understanding is the simultaneous pressure wave (SPW), an apparent instantaneous transient pressure development in the entire colon. Our aim was to provide a characterization of this motor pattern, its relationship to other motor patterns and its appearance in response to a meal, balloon distension and bisacodyl in healthy subjects. High-resolution colonic manometry (HRCM) was performed using an 84 sensor (1 cm spaced) water-perfused catheter in 16 healthy volunteers. Intraluminal pressure patterns were recorded during 90 min baseline, during balloon distension, 90 min after a meal and after luminal bisacodyl administration. Quantification was performed using software, based on Image J, developed during this study. SPWs, with amplitudes ranging from 2.4 to 75.2 mmHg (average 12 mmHg) and duration from 2 to 75s (average 11s), occurred throughout the entire colon or they developed at the termination of proximal High-Amplitude Pressure Waves (HAPWs). SPWs progressed into the anal canal followed by anal sphincter relaxation, even at very low amplitudes. SPWs did not obliterate haustral boundary contractions, likely the mechanism by which in vivo gas can escape while stool is retained. SPWs consisted of multiple high frequency, high velocity, pressure waves that resulted in apparent instantaneous pressure development. Balloon distension, a meal or luminal bisacodyl stimulation (10 mg) resulted in high amplitude SPWs associates with gas, water or balloon expulsion. SPWs and HAPWs also occurred independently and then did not influence each other. SPWs occurred in a rhythmic fashion on 26 occasions, including responses to all different stimuli; a distinct rhythmicity was identifiable at an average frequency of 1.8 ± 0.8 cpm, ranging from 0.3 to 4.4 cpm; 13 of the clusters were observed in response to the meal where the average frequency was 2.1 ± 0.9 cpm. The SPWs need to be incorporated into colonic function assessment by HRCM alongside HAPWs. It is the dominant motor pattern that allows gas expulsion and internal anal sphincter relaxation. Low- and high-amplitude SPWs are observed during baseline and are evoked by a meal, balloon distension or luminal bisacodyl. The rhythmicity of SPWs suggests the involvement of the ICC network at the submucosal border of the colon. The associated gas/liquid/balloon expulsion and anal sphincter relaxation provide potential diagnostic value. Their association with HAPWs suggest involvement in the defecation reflex. High resolution allows accurate quantification and 3-dimensional representation. High-Resolution Colonic Manometry. A proximal pressure wave, an SPW, throughout the entire colon, IAS relaxation, and a brief EAS contraction CIHRHamilton Health Sciences Organization and Canadian Foundation for Innovation John Evans Leadership Fund
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Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,001 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,002 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».