A287 REACTIVITY OF THE EXTRINSIC AUTONOMIC NERVOUS SYSTEM ASSOCIATED WITH HUMAN COLONIC MOTOR PATTERNS
Notice bibliographique
Résumé
The role of the autonomic nervous system (ANS) in control of colonic motility is unclear. Measurement of heart rate variability may provide diagnostic information for patients with colonic dysmotility. We explored relationships between the cardiac output of the ANS through heart rate variability (HRV) and colonic motor patterns with or without sensation during high-resolution colonic manometry (HRCM) Ten healthy volunteers (33 ± 12 yrs; 6 male) received HRV testing in response to body position changes (supine, sitting, standing, walking). 4 weeks later HRCM was performed with synchronized HRV recording. The parasympathetic and sympathetic reactivities were evaluated by Respiratory Sinus Arrhythmia (RSA) and the Pre-Ejection Period (PEP) respectively. Colonic motor patterns were recorded at baseline and under provoking conditions: balloon distension, a meal and luminal bisacodyl To assess general parasympathetic and sympathetic tone, body position change from supine condition to walking showed a decline in RSA from 6.7 ± 0.8 to 5.4 ± 0.7 (P<0.05), suggesting a decrease in parasympathetic activity; the PEP did not show significant change from 123.2 ± 20.0 to 113.3 ± 16.5 (P>0.05). Colonic motor complexes, multiple high amplitude pressure waves (HAPWs) with or without simultaneous pressure waves (SPWs)(n=47), were induced by balloon distention or luminal bisacodyl. During their occurrence, RSA was increased from 6.7 ± 1.2 to 7.5 ± 1.1 (P<0.001) and PEP was increased from 110.5 ± 15.3 to 116.3 ± 14.2 (P<0.0001), suggesting increased parasympathetic tone and decreased sympathetic tone. No significant autonomic change was observed during the occurrence of isolated HAPWs or SPWs. During HAPWs associated with SPWs and internal anal sphincter relaxation (n=30), RSA increased from 6.3 ± 1.1 to 6.8 ± 1.1 (P=0.005) and PEP did not show significant change (118.2 ± 11.1 to 121.4 ± 10.1; P=0.022), suggesting increased parasympathetic tone. In terms of the appreciable sensation (urge, discomfort, pain) during the occurrence of the motor pattern, both groups (109 out of 159 motor patterns with sensation and 50 out of 159 without sensation) showed increased RSA (from 6.4 ± 1.2 to 7.1 ± 1.2 and from 6.5 ± 1.2 to 6.9 ± 0.9, respectively; P<0.0001) and increased PEP (from 113.19 ± 14.90 to 115.5 ± 13.9, from 116.9 ± 10.43 to 119.32 ± 12.1, respectively; P<0.0001). There was no significant difference in RSA or PEP changes between these two groups (P>0.05), suggesting that is was motor activity that induced autonomic changes. Colonic motor complexes and HAPWs associated with SPWs, but not isolated HAPWs or SPWs, are associated with increased parasympathetic tone and decreased sympathetic tone, measured as increased RSA and PEP respectively. The associated sensation is not reflected in ANS changes. A colonic motor complex (2 high amplitude pressure waves (HAPWs) associated with 2 simultaneous pressure waves (SPWs) and IAS relaxation) was associated with an increase in RSA and a decrease in heart rate. CIHRHamilton Academic Health Sciences Organization and the Canadian Foundation of Innovation Evans Leadership Fund
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Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,001 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».