0748 Relationship Between Neurobehavioral Function And Sleep Depth In Children With Obstructive Sleep Apnea
Notice bibliographique
Résumé
Children with the obstructive sleep apnea syndrome (OSAS) have neurobehavioral deficits during wakefulness, such as executive function and memory deficits, poor school performance, hyperactivity and inattention. However, no polysomnographic measure has been able to predict neurobehavioral outcomes, and the pathophysiology behind these is still unknown. The Odds-Ratio-Product (ORP) is a continuous index of sleep depth derived from the relation of powers in different EEG frequency bands to each other. It is highly correlated with arousability. We utilized the polysomnograms of children with OSAS in the “Childhood Adenotonsillectomy Trial” (CHAT) to determine if changes in neurobehavioral measures from baseline to follow up are correlated with changes in sleep depth. CHAT participants were randomized to early adenotonsillectomy (eAT) or watchful waiting (WW) and underwent polysomnography (PSG) and neurobehavioral testing at baseline and 7 months after randomization. Baseline and follow-up PSGs were analyzed to obtain ORP, spindle density, power and intrinsic frequency (involved in learning and memory), alpha intrusion (% of non-REM epochs with alpha power>30μV2), and right-left EEG coherence. Changes in neurobehavioral measures between baseline and 7 months were regressed on changes in these sleep parameters and demographic variables using a stepwise model fitted and trimmed based on Akaike information criterion. When significant correlations were found we determined if the changes in the relevant variables were different between the eAT and WWSC groups. Here we present the relation between changes in sleep depth and neurobehavioral measures. 383 participants (age=median[IQR] 6.75[5.75–8.0]) were studied. Executive functioning measured by the Behavior Rating Inventory of Executive Function and hyperactivity symptoms changes reported by Conners scale were positively associated with non-REM-ORP changes (p=0.007 and 0.028, respectively). Improvements in sleep depth and in these neurobehavioral tests were significantly greater in eAT group (p<0.001). Changes in Developmental Neuropsychological Assessment (NEPSY)-Word Generation Semantic Scaled Score and Inhibition Naming Combined Scale were not associated with non-REM-ORP changes. Improvements in executive function and hyperactivity symptoms in children with OSAS following adenotonsillectomy are in part related to sleep depth improvement. K01HL130719 and UL1TR001878.
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Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,001 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,001 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».