SP647INTRADIALYTIC HYPERTENSION AND COGNITIVE FUNCTION IN INDONESIAN END STAGE RENAL DISEASE PATIENTS UNDERGOING HEMODIALYSIS- IS THERE A RELATION?
Notice bibliographique
Résumé
INTRODUCTION AND AIMS: Intradialytic Hypertension (IDH) is highly prevalent in Indonesian End Stage Renal Disease (ESRD) patients and is associated with adverse clinical outcomes. Patients with IDH exhibit imbalances in endothelial-derived vasoregulators, indirectly causing endothelial cell dysfunction and may cause structural abnormalities in the brain. One of the major consequences of this is cognitive impairment (CI). There have been numerous studies reporting about cognitive function in hemodialysis patients, however very little information is available about the relationship between IDH and cognitive function. The aim of this study is to find the relationship between IDH and CI in Indonesian ESRD patients undergoing routine hemodialysis. METHODS: A cross sectional study was carried out in three hemodialysis clinics in Jakarta, Indonesia. Patients which have undergone hemodialysis for > 3 months were included. IDH was defined as >10 mmHg increase in systolic BP in at least four of six prior consecutive hemodialysis sessions. Cognitive Function was assessed using Montreal Cognitive Assessment (MoCA-Ina) containing 7 domains. CI was defined as MoCA score <24. Bivariate analysis was done using Chi-Square test. RESULTS: A total of 93 patients were included in this study, out of which 61 (65.6%) were male. The mean age of the patients was 51.5 (±12.7) years. The etiology of chronic kidney disease is mostly due to hypertension (59.1%) followed by diabetes (26.9%). There were 40 (43.0%) patients that had IDH. There were 65 (69.9%) patients that had CI. The median scores of visuospatial, naming, attention, language, abstraction, delayed recall and orientation domains were 3 (0-5), 3 (0-3), 4 (0-6), 2 (0-2), 1 (0-2), 0 (0-5) and 6 (0-6) respectively. Patients with IDH were significantly more likely to have CI (OR = 3.09; p = 0.021). CONCLUSIONS: Our study shows that there was significant association between IDH and CI in Indonesian ESRD patients undergoing routine hemodialysis. As physicians, we should pay more attention to IDH in order to reduce the likelihood for cognitive dysfunction. However, larger longitudinal studies need to be carried out to confirm this result.
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Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,001 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,001 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,001 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».