KOGNITIVNA DISFUNKCIJA U BOLESNIKA S PARKINSONOVOM BOLESTI U SPLITSKO-DALMATINSKOJ ŽUPANIJI
Notice bibliographique
Résumé
Objectives: The aim of this study was to review the prevalence of cognitive impairment in patients with Parkinson′s disease (PD) in Split-Dalmatia County, to investigate effects of other variables on the cognitive status and its impact on the patients’ quality of life. Subjects and methods: This descriptive cross-sectional study was conducted at the Department of Neurology. The study included 39 patients suffering from PD. The data was collected in the period from October 2017, ending in May 2018. We started the examination with an insight into the medical documentation where the demographic and medical information about our subjects were collected. Subjects were than examined and asked to fill out PD specific questionnaires: MoCA, Hoeh and Yahr scale, UPDRS, PDQ-39, daily activity scales by Schwab and England. In order to analyze the given variables we used Mann-Whitney U test, Shapiro-Wilk test, and the Pearson coefficient of correlation. Results: Most of the patients who participated in the research scored less than 26 points on the MoCA questionnaire, which indicates a mild cognitive impairment and/or dementia. There hasn’t been found a statistically significant difference among men and women in the results of the MoCA questionnaire. Age has proven to be a risk factor for the development of cognitive dysfunctions. The duration of the disease did not affect the cognition test results. The MoCA questionnaire domains of visuospatial/executive abilities, attention, language, abstract thinking, and delayed recall showed statistically significant difference in outcome between patients with cognitive impairment (MoCA<26) and with normal cognition. A connection was established between results of the MoCA questionnaire and the stage of disease by Hoehn and Yahr. Patients in the severe stage of disease achieved the worst results. A correlation was also established between the MoCA questionnaire results and the UPDRS scale that tracks the development of the disease symptoms. As a result of the progression of motor symptoms of the disease and a consequently higher average of the use of levodopa, the cognitive ability of patients with PD is in decline. A correlation was also found between the quality of life and cognitive assessment tests. Individuals with a better quality of life performed better results on cognitive assessment tests. Conclusions: Cognitive dysfunction in the range of mild cognitive impairment to dementia is common symptom of PD patients. A common symptoms in PD patients are cognitive deficit, specifically in the domains of the visuospatial/executive abilities, attention, language, abstract thinking and delayed recall. The age of patient during the diagnosis of the disease and at the time of the survey has a negative impact on cognitive abilities, whereas sex and length of the disease do not affect cognitive abilities. Patients in the severe stage of disease achieved the worst results on the MoCA questionnaire. Cognitive functions affect the patient’s quality of life to a great extent.
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Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,000 |
| Bibliométrie | 0,003 | 0,002 |
| Études des sciences et des technologies | 0,001 | 0,001 |
| Communication savante | 0,001 | 0,001 |
| Science ouverte | 0,000 | 0,001 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,001 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».