Use of droxidopa for the long-term treatment of neurogenic orthostatic hypotension
Notice bibliographique
Résumé
This commentary refers to ‘2018 ESC guidelines for the diagnosis of syncope’, by M. Brignole et al., pages 1883–1948. Orthostatic hypotension (OH) can cause serious and potentially disabling symptoms and is associated with an increased risk of morbidity and mortality, particularly because of hazards from falls.1 The 2018 European Society of Cardiology (ESC) guidelines for the diagnosis and management of syncope provide clinicians with important updates regarding the recognition and treatment of OH.2 These guidelines outline the utility of droxidopa as a treatment for symptomatic OH due to autonomic failure [neurogenic OH (nOH)] based on data from short-term Phase 3 clinical trials. Recent data from a 12-month open-label extension study of droxidopa in patients with symptomatic nOH suggest the durability of benefits with long-term droxidopa treatment, including sustained increases in standing blood pressure and, more importantly, sustained improvements in patient-reported assessments of nOH symptom severity, in symptom effect on daily activities, and in the Clinical Global Impressions scale.3 The long-term efficacy of droxidopa treatment was also evaluated in a 6-month prospective study of patients with nOH initiating droxidopa treatment. This patient cohort reported improvements in falls, functionality, depressive symptoms, and health-related quality of life (HRQoL) with droxidopa treatment.4 Specifically, fewer patients reported a fall in the 1 month after initiating droxidopa treatment vs. the month before treatment (43% vs. 53%; P = 0.004); this reduced rate of falls was maintained at 6 months (40%; P = 0.034 vs. baseline). Other patient-reported assessments also showed significant improvements, including better functionality (Sheehan Disability Scale global scores, P ≤ 0.001), fewer depressive symptoms (Patient Health Questionnaire-9 scores, P < 0.01), and improved HRQoL (Short Form-8 scores, P ≤ 0.01). Taken together, the results of these studies suggest that long-term treatment with droxidopa provides sustained benefits to patients with nOH, although there are limitations due to the lack of parallel control groups and the self-reported nature of the data. As noted in the ESC guidelines,2 further research into treatment options for OH and the clinical effects of droxidopa is warranted to better guide effective management of patients with this challenging clinical condition. Editorial support was provided by CHC Group (North Wales, PA, USA). Editorial support was funded by Lundbeck. S.R.R. is a network investigator of the Cardiac Arrhythmia Network of Canada (CANet; London, Ontario, Canada). Conflict of interest: S.R.R. is a consultant/advisory board member for Lundbeck, GE Healthcare, Allergan Pharmaceuticals, Abbott Medical, and Boston Scientific Corporation. L.A.H. is an employee of Lundbeck.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,001 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».