P677 Effect of late faecal loss of infliximab on treatment response of inflammatory bowel disease
Notice bibliographique
Résumé
Anti TNF drugs are being used commonly in treatment of severe or non-responding cases of inflammatory bowel disease. Hence there are still some patients who are non-responder to these drugs or they lose their response throughout the course of treatment. Recently it has been proposed that loss of these drugs to the colonic lumen through the inflamed bowel may be responsible for the lack of response in the first 2 weeks of therapy. We evaluate the association of serum and faecal level of Anti TNF in patient treatment response. In this cohort study 28 patient were included during June 2016 to June 2017 at Imam Khomeini Hospital. Serum and faecal infliximab level were measured by enzyme-linked immunosorbent assay. The severity of Crohn’s disease was assessed by Crohn's disease activity index (CDAI) and UC severity was determined by Montréal classification at initiation of therapy and then on Day 14 and Week 24 of therapy. There was significant difference between serum infliximab level on Day 14 and 96 in crohn's disease (p value: 0.03). But was not seen in ulcerative colitis patients (p value: 0.7).The mean serum infliximab level on Day 96 was 2.3 µg/ml and 5.2 µg/ml in non-responder and responder groups, respectively, and showed significant difference in both ulcerative colitis and Crohn's disease patients. The mean faecal infliximab level on Day 14 and 96 was 11 µg/ml and 5 µg/ml, respectively, and showed no significant difference between responder and non-responder groups. There was an insignificant indirect relationship between serum and faecal infliximab level in UC patients (R = 0.401, p = 0.175) whereas this relationship was directly insignificant in crohn disease (R = −0.411, p = 0.239). There was a significant direct relationship between faecal infliximab level and CRP on Day 96 (R = 0.839, p = 0.002). We showed that faecal infliximab level other than the first days of treatment does not affect the treatment response. Although it was shown that increased faecal infliximab on first days of treatment is related to loss of response in UC patients, our study did not find significant relation in faecal infliximab with response to treatment on Week 24 in both crohn's and UC patients, but our results were matched with previous studies to show the relation of response with serum infliximab level. Decreased level CRP was related to increased level of faecal infliximab just in crohn's patients. Our study revealed that late faecal ant TNF concentration will not affect the treatment response and may not be a good predictor of response. Further studies will be needed to evaluate this relationship.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,002 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,003 | 0,001 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».