P269 Utility of capsule endoscopy in the diagnosis of inflammatory bowel disease and its disease extent
Notice bibliographique
Résumé
Capsule endoscopy is an established non-invasive tool for the evaluation of small bowel due to its ability to visualise subtle mucosal abnormality that may not be detected by cross-sectional imaging. We aim to evaluate its utility in patients with suspected inflammatory bowel disease (IBD) and in known IBD patients in a single tertiary hospital. Retrospective analysis was done for all patients who underwent capsule endoscopy with PillCam™ SB video capsule system from the National University Hospital, Singapore from January 2006 to December 2016. Clinical data, laboratory results, and medications were assessed using electronic medical records and electronic prescription. Statistical analysis was done using SPSS. Categorical variables were compared using χ2 test with Fisher exact test and continuous variables were compared using Student’s t-test where appropriate. There were 426 patients who underwent capsule endoscopy from January 2006 to December 2016. Among these, 35 (8.2%) patients underwent capsule endoscopy for suspected IBD while 16 (3.8%) patients underwent capsule endoscopy for known IBD. There were 19 (37.3%) patients in the paediatric age group and 32 (62.7%) patients in the adult age group. Thirty-one (60.7%) patients were males and 20 (39.2%) patients were females. Of the 35 patients with suspected IBD, 7 (20.0%) patients were diagnosed with IBD after capsule endoscopy was done. Suspected IBD patients who were subsequently diagnosed with IBD following capsule endoscopy had a significantly lower mean albumin level (39 ± 4.41 g/l) compared with patients who were not diagnosed with IBD (39.0 ± 4.41 g/l vs. 43.0 ± 3.28 g/l; p = 0.039), and were more likely to have hematochezia (3/7; 42.9% vs. 2/28; 7.1%, p = 0.044). There were no significant difference in haemoglobin, white cell count, C-reactive protein, creatinine, presence of diarrhoea, and weight loss, between patients who were subsequently diagnosed with IBD and those who were not. Among the 16 patients with known IBD, there was a change in IBD phenotype following capsule endoscopy in 2 (12.5%) patients, with extension of involvement from Montreal L2 (colonic) to L3 (ileocolonic) . Four (25.0%) patients had intensification of treatment following capsule endoscopy: one patient was started on biologics and 3 others were started on immunomodulators. Although IBD-related evaluation compromised a small proportion of overall capsule endoscopy referrals, capsule endoscopy is a useful tool in making the diagnosis of IBD, and in the evaluation of the extent of IBD, resulting in optimisation of treatment.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,004 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,002 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,001 | 0,001 |
| Science ouverte | 0,000 | 0,001 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,003 | 0,001 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».