Extemporaneous compounding for children with coronary heart diseases in Jamaica
Notice bibliographique
Résumé
Background: Coronary heart disease (CHD) has an incidence of approximately 8 per 1,000 live births globally. Treatment of pediatric CHD is largely dependent on underlying cause and the child's age. Drug therapy is commonly employed for managing children with cardiac failure and other heart related conditions. Overall, few drugs are approved for use in pediatric patients, guided by evidence-based trials conducted in adult population. Studies in Europe, North America and Canada indicate that about 80% of prescriptions for managing pediatric heart conditions are used as unlicensed or as off-label products. Such studies in the Caribbean populations are lacking in the literature. This study was therefore designed to investigate the methods by which children with heart failure are being managed in Jamaica, West Indies. Method: A real-time prescription screening and retrospective survey of compounding record of medications compounded and dispensed for children age 0 to 12 years was done during a period of 12 months at the Bustamante Hospital for Children, Jamaica. A validate data sheet was used to collect demographic (child's age, gender), diagnostic and pharmacotherapeutics data on patients after securing informed consents from their parents. In addition, historical data were extracted from an onsite compounding logbook. Pharmacotherapeutics information include drug prescribed, dose size and dosing frequency, dosage form and its age-appropriateness of medication prescribed. For lack of age-appropriate medications, compounding or modification performed, volume compounded and dispensed extracted. Data were analyzed using SPSS Version 19 and MS Excel. Results: a total of 3,747 prescriptions were surveyed with 10,797 items prescribed. Of the items prescribed heart specific medicines represented 5.23% (565). The mean age of children was 62.55 months (SD = 31.02) with 53.33% of them being male patients. Among the top twenty drugs prescribed for children, only three (3) were for cardiovascular indication i.e. Captopril (1.33%), furosemide (3.49%) and spironolactone (3.35%). Approximately 76.11% of these prescriptions was either compounded or manipulated to provide child-appropriate dosage forms. Conclusion: Extemporaneous compounding is still being used to provide age-appropriate dosage forms for pediatric patients with heart disease in Jamaica. Therefore, there is ongoing need for validation of compounding practices with regard to the quality of the practice and the quality of the finished preparations
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,002 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».