Cronkhite-Canada Syndrome Presenting as Acute Colitis; Confirmed by Colonoscopy, Upper Endoscopy, Capsule Endoscopy, and Pathology
Notice bibliographique
Résumé
Cronkhite-Canada syndrome is a rare disease first described in 1955. The clinical features include diarrhea, nail dystrophy, alopecia, and hyperpigmentation of the skin. We describe a case of Cronkhite-Canada Syndrome presenting as acute colitis with evidence of disease found on upper endoscopy, sigmoidoscopy, and capsule endoscopy. A 49 year old male presented to the Emory University GI clinic with total body hair loss and bloody diarrhea which began suddenly six weeks prior to presentation. He described the diarrhea as loose, predominantly liquid stool with red blood mixed in occuring 4–5 times per day. The diarrhea also occurs at night and wakes the patient from sleep. He was seen by a gastroenterologist who performed a colonoscopy and was found to have erythema throughout his colon. He was diagnosed with indeterminate colitis from a biopsy showing mucin filled crypts and chronic active inflammation without malignancy and started on 5-ASA therapy without improvement. At the time of presentation to our clinic, he had no remaining hair on his head and had also lost his eyelashes and body hair including his pubic hair. He also reported that he had lost his finger nails and toe nails. In addition he had a fifty pound weight loss and systemic fatigue. He also reported alterations in his sense of smell and a decreased appetite because food no longer tasted good. Physical exam was notable for diffuse hair loss including loss of his eyelashes, loss of his finger nails and toe nails but was otherwise unremarkable. Upper endoscopy and flexible sigmoidoscopy were repeated in addition to capsule endoscopy for additional evaluation. The upper endoscopy was remarkable for nodular, friable, erythematous gastic mucosa. There was also duodenitis with erythema and ulcerations noted. The esophageal mucosa was normal. The flexible sigmoidoscopy demonstrated erythematous and friable mucosa from the rectum to the transverse colon with exudative ulcerations. Capsule endoscopy showed diffuse, nodular erythematous mucosa throughout the entire small bowel. After a thorough review of the patient's history, physical exam and discussion with our pathologist the diagnosis of Cronkhite-Canada Syndrome was made and treatment was started. The patient was treated with antihistamines, H-2 blockers, prednisone, and the first reported use of the antibiotic Rifaximin for the treatment of Cronkhite-Canada Syndrome with a good response.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,002 |
| Méta-épidémiologie (sens strict) | 0,002 | 0,001 |
| Méta-épidémiologie (sens large) | 0,001 | 0,000 |
| Bibliométrie | 0,002 | 0,002 |
| Études des sciences et des technologies | 0,002 | 0,001 |
| Communication savante | 0,001 | 0,001 |
| Science ouverte | 0,001 | 0,001 |
| Intégrité de la recherche | 0,002 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,002 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».