RETRACTED ARTICLE: Evolution of substrate-specific gene expression and RNA editing in brown rot wood-decaying fungi
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Dossier post-publication
- Nature
- Retraction
- Motif
- Error in Analyses;Error in Methods;
- Date
- 12/1/2021 0:00
- Signalé par OpenAlex ?
- Oui
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Résumé
Fungi that decay wood have characteristic associations with certain tree species, but the mechanistic bases for these associations are poorly understood. We studied substrate-specific gene expression and RNA editing in six species of wood-decaying fungi from the 'Antrodia clade' (Polyporales, Agaricomycetes) on three different wood substrates (pine, spruce, and aspen) in submerged cultures. We identified dozens to hundreds of substrate-biased genes (i.e., genes that are significantly upregulated in one substrate relative to the other two substrates) in each species, and these biased genes are correlated with their host ranges. Evolution of substrate-biased genes is associated with gene family expansion, gain and loss of genes, and variation in cis- and trans- regulatory elements, rather than changes in protein coding sequences. We also demonstrated widespread RNA editing events in the Antrodia clade, which differ from those observed in the Ascomycota in their distribution, substitution types, and the genomic environment. Moreover, we found that substrates could affect editing positions and frequency, including editing events occurring in mRNA transcribed from wood-decay-related genes. This work shows the extent to which gene expression and RNA editing differ among species and substrates, and provides clues into mechanisms by which wood-decaying fungi may adapt to different hosts.
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La notice
- Revue
- The ISME Journal
- Thématique
- Insect symbiosis and bacterial influences
- Domaine
- Agricultural and Biological Sciences
- Établissements canadiens
- University of Toronto
- Organismes subventionnaires
- Joint Genome InstituteU.S. Department of EnergyOffice of ScienceNational Science Foundation
- Mots-clés
- BiologyGeneGene expressionGeneticsBotanyComputational biologyEvolutionary biology
- Résumé présent dans OpenAlex
- oui