Yiqi-Huoxue Granule (YQHX) Downregulates Prothrombotic Factors by Modulating KLF2 and NF-<i>κ</i>B in HUVECs following LPS Stimulation
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- Nature
- Retraction
- Motif
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- Date
- 1/9/2024 0:00
- Signalé par OpenAlex ?
- Oui
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Résumé
The Yiqi-Huoxue granule (YQHX) is a traditional Chinese medication widely used in the therapy of the traditional Chinese medicine diagnosis “Qi deficiency” or “blood stasis” in China. Both these symptoms are related to inflammation, but the mechanisms of YQHX against inflammation are largely unknown. Thus, our present study investigated the effects of YQHX on regulating inflammatory responses induced by lipopolysaccharides (LPS) in HUVECs. Our data found that YQHX remarkably inhibits the production of prothrombotic factors, plasminogen activator inhibitor-1 (PAI-1) and tissue factor (TF), while it upregulates the protein expression of Kruppel-like factor 2 (KLF2). The increase in PAI-1 and TF was significantly attenuated through a transgenic knockdown in KLF2 with a Lenti-shKLF2 vector. YQHX also decreases the phosphorylation of nuclear factor- κ B (NF- κ B) p65 and I κ B following LPS stimulation, and it effectively suppresses PAI-1 and TF via a NF- κ B-dependent mechanism. Taken together, our results suggest that YQHX provides a notable antithrombotic activity via regulating the KLF2 expression and NF- κ B signaling pathway in HUVECs. The KLF2 and NF- κ B may be potential therapeutic targets for interventions of inflammation associated with atherosclerosis.
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La notice
- Revue
- Oxidative Medicine and Cellular Longevity
- Thématique
- Kruppel-like factors research
- Domaine
- Biochemistry, Genetics and Molecular Biology
- Établissements canadiens
- Memorial University of Newfoundland
- Organismes subventionnaires
- National Natural Science Foundation of China
- Mots-clés
- KLF2InflammationGene knockdownTissue factorNF-κBIκBαStimulationNFKB1Tissue factor pathway inhibitorActivator (genetics)Tissue plasminogen activatorSignal transductionPlasminogen activator inhibitor-1PharmacologyPlasminogen activatorCancer researchImmunologyChemistryCell biologyBiologyMedicineDownregulation and upregulationInternal medicineEndocrinologyApoptosisTranscription factorCoagulationBiochemistryReceptor
- Résumé présent dans OpenAlex
- oui