P136 Association between histological indices and ulcerative colitis activity measures among patients in the HICKORY (etrolizumab) open-label induction cohort
Notice bibliographique
Résumé
Cross-sectional studies in UC have shown an association between histological and clinical measures of disease activity, but few longitudinal studies have evaluated this relationship.1,2 Using data from the open-label induction (OLI) cohort of HICKORY,3 we evaluated the correlation between histological changes and established disease activity measures at end of induction (Week 14). Baseline and Week 14 biopsies were scored by 4 central readers using the Robarts histopathology index (RHI) and the Nancy histological index (NHI) in patients who had active baseline histology (NHI > 1 and RHI > 3) and complete scoring at Week 14 (n = 97). Binary Week 14 histological outcomes were characterised by presence or absence of neutrophils (NHI ≤ 1 or RHI ≤ 3 and Geboes subgrades 2B.0/3.0). Pairwise associations were quantified by Spearman correlation (ρ; for correlation between change from baseline scores) and Cohen's kappa coefficients (κ; for agreement among Week 14 outcomes). ΔRHI and ΔNHI were compared with determine the presence of a minimal clinically important difference (MCID) in Mayo Clinic score (MCS; ∆MCS ≥ 3). MCS endoscopic subscore (ES) was used to assess endoscopy. At Week 14, 22% (21/97), 23% (22/97) and 8% (8/97) of patients achieved resolution of neutrophilic inflammation, endoscopic improvement (ES ≤ 1) and endoscopic remission (ES=0), respectively; NHI ≤ 1 was achieved in 55% (12/22) of patients with ES ≤ 1 and 75% (6/8) of patients with ES = 0. ΔNHI and ΔRHI were highly correlated (ρ = 0.91). There was little to no association between laboratory results and ΔNHI/ΔRHI/ΔES (Figure 1A). A weak correlation was seen between ΔNHI/ΔRHI and ΔES (ρ = 0.26–0.27) and between ΔNHI/ΔRHI and change in rectal bleeding and stool frequency. NHI, RHI and ES agreement with symptomatic outcomes were weak to moderate (κ = 0.28–0.45; Figure 1B). Difference in the mean grouped by achievement of ΔMCS ≥3 suggests MCIDs in ΔNHI and ΔRHI of 1 and 9, respectively (Table 1). Figure 1. (A) Pairwise Spearman correlation coefficients between change from baseline scores at Week 14 and disease activity measures and (B) Pairwise Cohen’s kappa coefficients among Week 14 outcomes. Abstract PO136 – Table 1. Baseline and Change from Baseline in NHI and RHI by Achievement of MCID in MCS (∆MCS≥3) in NHI- and RHI-evaluable Patients The analysis showed no associations between changes in histological scores and changes in laboratory results, a weak correlation between changes in histological and endoscopic scores, and a weak to modest correlation between histological scores and symptoms at the end of induction. References 1. Bessissow T, Lemmens B, Ferrante M, et al. Prognostic value of serologic and histologic markers on clinical relapse in ulcerative colitis patients with mucosal healing, Am J Gastroenterol, 2012;107:1684-92. 2. Christensen B, Hanauer SB, Erlich J, et al. Histologic normalization occurs in ulcerative colitis and is associated with improved clinical outcomes. Clin Gastroenterol Hepatol 2017;15:1557–64. 3 Rubin DT, Feagan BG, Peyrin-Biroulet L, et al. Tu2006—etrolizumab induction therapy improves histologic outcomes in anti-TNF-failed patients with ulcerative colitis: results from the Hickory Open-Label Induction cohort. Gastroenterology. 2018;S-1366
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,003 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,001 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,001 | 0,001 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,005 | 0,001 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».