Response
Notice bibliographique
Résumé
To the Editor-in-Chief, We would like to thank Dr. Coggan for a positive and succinct summary of our findings, and for concurring with our main assertion that protein modifications, and not protein expression, likely contribute to the ergogenic effects of nitrate consumption within skeletal muscle. Nevertheless, Dr. Coggan has taken exception to the statement in our published work that “future studies should also include an assessment of changes in function after acute ingestion.” However, the following sentence in that work gets at the main point we were trying to highlight, namely, that to our knowledge, mechanistic work has not been performed after a single bolus of nitrate consumption. Specifically, previous work examining calcium handling (1,2), mitochondrial coupling (3–5), and mitochondrial reactive oxygen species emission (4) have all been conducted after repeated intake (i.e., ≥3 d) of oral nitrate. Therefore, although there are numerous examples showing that a single intake of oral nitrates can improve human exercise performance (only some of these seminal articles are referenced within our manuscript [6,7], because of the journal’s restriction on the number of references), we stand by our assertion that future research is required to delineate the specific mechanisms associated with an acute intake of nitrate. In our recent work, we hypothesized that changes in human skeletal muscle contractile function after nitrate supplementation could be explained by structural and/or redox-mediated changes, but we were unable to detect a change in the redox status of skeletal muscle (2). However, we acknowledge that the measurements made represent a snapshot of cellular oxidative stress and may therefore lack the sensitivity to accurately determine redox signaling. As such, future research is required in all potential aspects of signaling after nitrate supplementation, and the utilization of advanced techniques and -omics strategies may prove beneficial in delineating the physiological significance of the previously observed increase in H2O2 emission (4). Furthermore, given the similarities in muscle function with acute and chronic nitrate consumption, the logical progression in our minds would be to use an experimental design focused on the changes seen after an acute bolus of nitrate. We feel that the findings of such a study would be important, because it may further our understanding of the mechanistic underpinnings of nitrate supplementation, as well as help inform researchers and practitioners how to appropriately tailor supplementation protocols across different populations. Jamie Whitfield Mary Mackillop Institute for Health Research Australian Catholic University Melbourne, VIC AUSTRALIA George J. F. Heigenhauser Department of Medicine McMaster University Hamilton, ON CANADA Luc J. C. van Loon Department of Human Movement Sciences Nutrition and Toxicology Research Institute Maastricht University Maastricht, the NETHERLANDS Lawrence L. Spriet Department of Human Health and Nutritional Sciences University of Guelph Guelph, ON CANADA A. Russell Tupling Department of Kinesiology University of Waterloo Waterloo, ON CANADA Graham P. Holloway Department of Human Health and Nutritional Sciences University of Guelph Guelph, ON CANADA
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,005 | 0,003 |
| Méta-épidémiologie (sens strict) | 0,001 | 0,000 |
| Méta-épidémiologie (sens large) | 0,002 | 0,000 |
| Bibliométrie | 0,002 | 0,003 |
| Études des sciences et des technologies | 0,000 | 0,006 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,001 | 0,000 |
| Intégrité de la recherche | 0,001 | 0,002 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,004 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».