A167 ANTIMICROBIAL SUSCEPTIBILITY OF HELICOBACTER PYLORI IN THE SASKATOON HEALTH REGION
Notice bibliographique
Résumé
Helicobacter pylori infection has been implicated in the development of duodenal or gastric ulcers, early gastric cancer and gastric mucosa-associated lymphoid tissue lymphomas. The increasing prevalence of antibiotic-resistant strains of H pylori have led to reduced success with traditional H pylori treatments; with some studies reporting eradication in less than 50% of cases. There has been no study completed, to this date, which has investigated regional antibiotic resistance patters of H pylori in the Saskatoon Health Region. Primary Outcome: Is to assess the susceptibility of H. pylori strains isolated from gastric biopsies of patients with peptic ulcer disease to Amoxicillin, Metronidazole, Clarithromycin, Tetracycline, Levofloxacin, Moxifloxacin, and Rifabutin. Secondary Outcome: 1) Standardizes the treatment of H pylori in the Saskatoon Health Region 2) Reduction in healthcare costs associated with inappropriate antibiotic prescribing 3) Analyze potential predictors of H pylori resistance 4) Accuracy of CLO test versus histology in the diagnosis of H pylori This is a prospective study patients suspected to have peptic ulcer disease typically undergo an EGD and biopsies are removed to test for H pylori. For our study, additional biopsies will undergo a CLO test. If the CLO test is positive, the biopsy sample will be sent to the clinical microbiologist for culture and susceptibility testing. We will be looking at the susceptibility of the 50 strains of H pylori to 7 antibiotics, which include: Amoxicillin, Metronidazole, Clarithromycin, Tetracycline, Levofloxacin, Moxifloxacin, and Rifabutin. Prior to undergoing an EGD patients will be invited to participate in a survey, which will collect demographic, lifestyle factors, history of H pylori and treatment and EGD diagnosis. Unfortunately, our project was initiated recently and our results are preliminary. To date, 14 patients have been enrolled of which half are male. The mean age of our cohort is 55.3 (13.5) without a significant age discrepancy between sexes. In our enrolled cohort to date, the CLO test has perfect specificity (100%) but lacks sensitivity (50%). The relative risk of patients who identify as “East Asians” or “First Nations” having H pylori was 14. A McNemar’s test with continuity correction determined that both the CLO test and pathology results were statistically comparable to one another (p < 0.001). Antimicrobial susceptibility testing results for specimens were pending at the time of this report submission. For a cohort size of 14 patients, we have demonstrated and validated the reliability and specificity of CLO test in comparison to histology in the diagnosis of H pylori. Our project is promising and we hope to continue recruitment. Most importantly, our project has economical insights, as we continue to analyze results in our growing cohort. None
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».