The Relationship Between Urban Environment and Inflammatory Bowel Disease: A Systematic Review and Meta-analysis
Notice bibliographique
Résumé
Purpose: Residing in an urban environment has been associated with the inflammatory bowel diseases (IBD). The objectives of our study were to conduct a systematic review with meta-analysis of studies assessing the association between urban environment and both ulcerative colitis (UC) and Crohn's disease (CD). Methods: A systematic literature search of MEDLINE (1950 to Oct. 2009) and EMBASE (1980 to Oct. 2009) databases was conducted to identify studies investigating the relationship between urban environment and IBD. The search was not limited by language to ensure capture of all appropriate papers. Two reviewers identified eligible articles based on the following pre-determined criteria: (1) investigated environmental risk factors for IBD in a case-control design or investigated the epidemiology of IBD using incident cases; (2) reported or provided enough information to calculate a measure of association between urban environment and IBD; and (3) UC and/or CD were reported separately. Studies not based on original data were excluded. Cohort and case-control studies were analyzed using incidence rate ratio (IRR) and odds ratio (OR) with 95% CIs, respectively. Random effects analyses were used given the potential heterogeneity between studies. Stratified and sensitivity analyses were performed to explore factors that may explain heterogeneity between studies (e.g. publication year, geographic region, timing of exposure) and to assess the effects of selected study quality. Results: The search strategy retrieved 6940 unique citations and 30 studies were selected for inclusion. Of these, 20 investigated the relationship between urban environment and UC and 22 investigated this relationship with CD. Therefore, included in our analysis were 5 case-control UC studies, 7 case-control CD studies, 15 cohort UC studies and 15 cohort CD studies. Based on a random effects model, the pooled IRRs for UC and CD cohort studies were 1.20 (1.02, 1.41) and 1.37 (1.20, 1.58), respectively. For case-control studies the pooled ORs for UC and CD were 1.28 (0.99, 1.65) and 1.35 (1.23, 1.62), respectively. These associations persisted across multiple stratified and sensitivity analyses exploring clinical and study quality factors. Heterogeneity was observed in the cohort studies for both UC and CD, whereas statistically significant heterogeneity was not observed for the case-control studies. Conclusion: A positive association between urban environment and both CD and UC was found. Heterogeneity may be explained by differences in study design and quality factors.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,018 | 0,046 |
| Méta-épidémiologie (sens strict) | 0,003 | 0,002 |
| Méta-épidémiologie (sens large) | 0,020 | 0,026 |
| Bibliométrie | 0,012 | 0,015 |
| Études des sciences et des technologies | 0,001 | 0,001 |
| Communication savante | 0,004 | 0,002 |
| Science ouverte | 0,003 | 0,002 |
| Intégrité de la recherche | 0,002 | 0,002 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,003 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».