Transcatheter Aortic-Valve Replacement with a Self-Expanding Valve in Low-Risk Patients
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Résumé
BACKGROUND: Transcatheter aortic-valve replacement (TAVR) is an alternative to surgery in patients with severe aortic stenosis who are at increased risk for death from surgery; less is known about TAVR in low-risk patients. METHODS: We performed a randomized noninferiority trial in which TAVR with a self-expanding supraannular bioprosthesis was compared with surgical aortic-valve replacement in patients who had severe aortic stenosis and were at low surgical risk. When 850 patients had reached 12-month follow-up, we analyzed data regarding the primary end point, a composite of death or disabling stroke at 24 months, using Bayesian methods. RESULTS: ). CONCLUSIONS: In patients with severe aortic stenosis who were at low surgical risk, TAVR with a self-expanding supraannular bioprosthesis was noninferior to surgery with respect to the composite end point of death or disabling stroke at 24 months. (Funded by Medtronic; ClinicalTrials.gov number, NCT02701283.).
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La notice
- Revue
- New England Journal of Medicine
- Thématique
- Cardiac Valve Diseases and Treatments
- Domaine
- Medicine
- Établissements canadiens
- McGill University Health Centre
- Organismes subventionnaires
- Medtronic
- Mots-clés
- MedicineValve replacementStenosisCardiologyInternal medicineAortic valve stenosisAortic valve replacementSurgery
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- oui