MP59-17 COMPARISON OF SHORT-ACTING VS. LONG-ACTING TESTOSTERONE GELS ON FSH
Notice bibliographique
Résumé
You have accessJournal of UrologySexual Function/Dysfunction: Basic Research & Pathophysiology (MP59)1 Apr 2019MP59-17 COMPARISON OF SHORT-ACTING VS. LONG-ACTING TESTOSTERONE GELS ON FSH Thomas Masterson*, Gerwin Westfield, Nathan Bryson, Ross Ormsby, and Ranjith Ramasamy Thomas Masterson*Thomas Masterson* More articles by this author , Gerwin WestfieldGerwin Westfield More articles by this author , Nathan BrysonNathan Bryson More articles by this author , Ross OrmsbyRoss Ormsby More articles by this author , and Ranjith RamasamyRanjith Ramasamy More articles by this author View All Author Informationhttps://doi.org/10.1097/01.JU.0000556729.33156.b2AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVES: Low testosterone (low T) affects around 38.7% of men over the age of 45 and prescriptions to younger men is on the rise. Exogenous long-acting testosterone replacement therapy (TRT) can act as a contraceptive . Very few contemporary studies have evaluated the effect of TRT on gonadotropins and reproduction. Recently, Natesto®, a short acting intranasal gel given three times daily, was demonstrated to increase serum total testosterone while maintaining normal serum levels of gonadotropins. We hypothesized that due to Natesto's pulsatile (ultradian) systemic exposure, which simulates the pulsatile release of gonadotropin hormones from the HPG axis, it may have lesser effect on gonadotropins than longer acting testosterone gel preparations. We compared the effect of Natesto to a topical testosterone gel on serum FSH, as evidence has shown that FSH is critical for fertility and spermatogenesis METHODS: We performed a post hoc analysis of previously published studies on exogenous testosterone and FSH. Two studies were identified . One prescribing Natesto (11.0mg testosterone/dose, tid), and the other Testim® (50mg, 1% transdermal testosterone). We compared the changes in FSH after 3 months of therapy and in particular attempted to identify characteristics of men who had FSH < 1.5IU/ml as it was considered the lower limit of normal (LLN ). Results are presented as means (SD). Categorical variables were tested for statistical significance RESULTS: A total of 297 men were prescribed Natesto and 31 hypogonadal men were prescribed Testim (1%). Among the men who were prescribed Natesto, FSH changed from 8.2(11.0) to 5.5 (9.3) after 3 months. A total of 90 (30.3%) men had FSH < 1.5 after 3 months and 39 (12.1%) were ≤ 0.5. There were no differences in age or BMI between men who had undetectable FSH and those who did not. Among the 31 men who were prescribed Testim, FSH levels decreased from 6.0 (2.9) at baseline to 2.4 (2.8). Of the 31 men, 13 (41.9%) had FSH below LLN after 3 months. CONCLUSIONS: Testosterone therapy using Natesto increases testosterone while maintaining normal levels of FSH in 70% of men, compared to only 58% in steady state testosterone preparations. Identifying strategies to increase testosterone while simultaneously maintaining reproductive potential is critical for treating young men with low testosterone who wish to preserve fertility. Source of Funding: none Miami, FL; Denver, CO; Mississauga, Canada; Miami, FL© 2019 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 201Issue Supplement 4April 2019Page: e867-e867 Advertisement Copyright & Permissions© 2019 by American Urological Association Education and Research, Inc.MetricsAuthor Information Thomas Masterson* More articles by this author Gerwin Westfield More articles by this author Nathan Bryson More articles by this author Ross Ormsby More articles by this author Ranjith Ramasamy More articles by this author Expand All Advertisement PDF downloadLoading ...
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,002 | 0,002 |
| Bibliométrie | 0,001 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,001 | 0,001 |
| Science ouverte | 0,001 | 0,000 |
| Intégrité de la recherche | 0,001 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,030 | 0,002 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».