PD23-03 HIGH RESOLUTION 29 MHZ MICRO-ULTRASOUND IN THE DIAGNOSIS OF PRIMARY AND RECURRENT PROSTATE CANCER
Notice bibliographique
Résumé
You have accessJournal of UrologyImaging/Radiology: Uroradiology I (PD23)1 Apr 2019PD23-03 HIGH RESOLUTION 29 MHZ MICRO-ULTRASOUND IN THE DIAGNOSIS OF PRIMARY AND RECURRENT PROSTATE CANCER Laurence Klotz* and Dixon Woon Laurence Klotz*Laurence Klotz* More articles by this author and Dixon WoonDixon Woon More articles by this author View All Author Informationhttps://doi.org/10.1097/01.JU.0000555771.27764.d2AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVES: High resolution micro-ultrasound (micro-US) is a novel technology which offers the potential to image PCa and perform targeted biopsies with significantly improved cancer visualization compared to conventional ultrasound, potentially obviating the need for MRI. Micro-US incorporates a scoring system (PRIMUS, Grades 1-5) that is similar to the PIRADS-2 system used for MRI. This facilitates assignment of a risk category based on the characteristics of the region of interest. We evaluate the NPV and PPV for each PRIMUS risk category. METHODS: 50 patients underwent prostate biopsy using micro-US (ExactVu micro-US, Exact Imaging, Markham, Canada). 32 were undiagnosed men at risk for PCa, and 18 had been previously treated with focal therapy with HIFU or TULSA and were undergoing post treatment biopsies. In the undiagnosed patients, targeted and 12 core systematic biopsies were performed. 28 had had a prior MRI. Physicians were blinded to the MRI results at the time of biopsy. RESULTS: The NPV for PRIMUS scores <= 3 for clinically significant PCa was 96% (27/29). Of 19 cases with a PRIMUS 4 or 5 lesion, 63% had a positive biopsy. In 10 cases with GG ≥2, 9 (90%) had a PRI-MUS ≥3 lesion at the cancer location. The single GG ≥ 2 cancer missed on micro-US was a post-focal therapy case whose MRI was also negative. Of 28 cases who had both MRI and micro-US, 12 had a positive biopsy. 7/12 had targets seen on both modalities. 1/12 was negative on both; 4/12 had GG 2 with a positive micro-US and negative MRI. All patients with a PIRADS score 4-5 had a PRIMUS 4-5 lesion on micro-US at the same location. The PPV for each PRIMUS score for all PCa grades was 1: 0%, 2: 33%, 3: 29%, 4: 63%, 5: 67%, and for GG 2, 1: 0%, 2: 0%, 3: 4%, 4:38%, 5: 67%. CONCLUSIONS: High resolution micro-ultrasound with targeted biopsy appears to offer comparable sensitivity, specificity, PPV and NPV to MP-MRI, in the setting of both primary diagnosis and post-treatment recurrence. Micro-ultrasound-based biopsies combine imaging and targeting in a single session and involves substantially less cost and complexity than MRI combined with fusion targeting. Source of Funding: None. The Exact Vue system was provided by Exact Imaging, Markham Ontario Toronto, Canada© 2019 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 201Issue Supplement 4April 2019Page: e393-e394 Advertisement Copyright & Permissions© 2019 by American Urological Association Education and Research, Inc.MetricsAuthor Information Laurence Klotz* More articles by this author Dixon Woon More articles by this author Expand All Advertisement PDF downloadLoading ...
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,002 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,001 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,001 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,001 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,017 | 0,006 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».