PD20-02 CHARACTERIZATION OF CERVIX INNERVATION: RELEVANCE TO LOOP ELECTROSURGICAL EXCISION PROCEDURES
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Résumé
You have accessJournal of UrologySexual Function/Dysfunction: Female (PD20)1 Apr 2019PD20-02 CHARACTERIZATION OF CERVIX INNERVATION: RELEVANCE TO LOOP ELECTROSURGICAL EXCISION PROCEDURES Madeline Monaghan, Olivia Giovannetti, Johanna Hannan*, Barry Komisaruk, Sue Goldstein, Irwin Goldstein, and Michael Adams Madeline MonaghanMadeline Monaghan More articles by this author , Olivia GiovannettiOlivia Giovannetti More articles by this author , Johanna Hannan*Johanna Hannan* More articles by this author , Barry KomisarukBarry Komisaruk More articles by this author , Sue GoldsteinSue Goldstein More articles by this author , Irwin GoldsteinIrwin Goldstein More articles by this author , and Michael AdamsMichael Adams More articles by this author View All Author Informationhttps://doi.org/10.1097/01.JU.0000555734.67736.e3AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVES: The cervix has a well-recognized role in reproduction and pregnancy, but its function in female sexual response has yet to be fully clarified. Using functional MRI, Komisaruk et al (2011) showed that pressure stimulating the cervix activated the paracentral lobule in the genital sensory cortex, providing evidence that cervical sensory activity is perceptible. The triple afferent innervation of the cervix via the pelvic, hypogastric, and vagus nerves supports its multifaceted physiologic role. Inna et al (2010) reported significant negative deficits in overall sexual and orgasmic satisfaction after Loop Electrosurgical Excision Procedures (LEEP) for cervical dysplasia. The present study characterized the innervation of cervical tissue from hysterectomy specimens. METHODS: Seven tissue samples from Kingston General Hospital (Ontario), selected from an archive tissue bank from total hysterectomy procedures, were acquired and examined histologically. Tissue blocks from both the anterior and posterior walls of the cervix were used for analysis. The tissue included the cervical external os, around which the loop wire cuts during the LEEP procedure. RESULTS: A general nerve stain, protein gene product 9.5 (PGP9.5), showed overall innervation of the tissue. Further immunohistochemical analyses showed staining for subpopulations of nerves. The tissue stained positive for: cholinergic innervation [anti-choline acetyltransferase (ChAT) antibody]; adrenergic innervation [anti-tyrosine hydroxylase (TH) antibody]; and sensory innervation [anti-Nav1.8 (Nav1.8) antibody, Fig.1]. Comparison with PGP9.5 provided evidence of further innervation that may not be specific to ChAT, TH, or Nav1.8. Qualitative analysis of serial sections demonstrated many highly innervated vascular and glandular structures, as well as nerve fibers that appear to be travelling through the tissue. CONCLUSIONS: The cervix is a richly vascularized and innervated organ. Evidence of sensory innervation through Nav1.8 positive staining in and near the epithelium suggests that the LEEP procedure transects through these neural structures. Future studies will collect excised cervical tissue obtained from LEEP and morphologically reconstruct the LEEP excised tissue to understand the tissue’s structure and physiology. A greater knowledge of the tissue removed during LEEP will allow for modification of the surgical procedures to reduce the risk of post-LEEP sexual dysfunction. Source of Funding: None Kingston, Canada; Greenville, NC; Newark, NJ; San Diego, CA; Kingston, Canada© 2019 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 201Issue Supplement 4April 2019Page: e377-e377 Advertisement Copyright & Permissions© 2019 by American Urological Association Education and Research, Inc.MetricsAuthor Information Madeline Monaghan More articles by this author Olivia Giovannetti More articles by this author Johanna Hannan* More articles by this author Barry Komisaruk More articles by this author Sue Goldstein More articles by this author Irwin Goldstein More articles by this author Michael Adams More articles by this author Expand All Advertisement PDF downloadLoading ...
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,001 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,001 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,001 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,015 | 0,004 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».