PTH-126 Ten hz repetitive cerebellar magnetic stimulation reverses cortical suppression in the healthy human pharyngeal motor system
Notice bibliographique
Résumé
<sec><st>Introduction</st> There is good evidence for a role of the cerebellum in swallowing physiology and we have previously shown that longer-lasting changes of human pharyngeal motor cortex can be induced by 10 Hz repetitive transcranial magnetic stimulation (rTMS) applied to the cerebellum. This study aimed to examine the therapeutic potential and cerebellar hemispheric specificity of 10 Hz cerebellar rTMS by testing its ability to reverse focal cortical suppression induced by a virtual lesion over the (dominant) pharyngeal motor cortex in healthy humans. </sec> <sec><st>Method</st> Fifteen healthy volunteers (7 males, age range 19–49 years) participated and were intubated with an intraluminal catheter for recording pharyngeal electromyography (EMG). Baseline measurements of cortical excitability assessed through motor evoked potentials (MEP) at three sites (both dominant and non-dominant pharyngeal cortices and hand motor cortex) and cerebellar excitability in each cerebellar hemisphere were obtained by single-pulse TMS. Thereafter, each subject received 1 Hz rTMS (for 10 min at an intensity of 120% of resting motor threshold) to dominant pharyngeal motor cortex to transiently suppress cortical swallowing activity. Subsequently, subjects were randomised to receive one of three cerebellar 10 Hz rTMS interventions (ipsilesional cerebellar hemisphere, contralesional cerebellar hemisphere and ipsilesional sham). Post-intervention, cortical (pharynx and hand) and cerebellar MEPs were re-measured for up to 60 min and compared to sham using repeated measures and one way ANOVA. </sec> <sec><st>Results</st> As there was no difference in the pattern of excitability between each cortical hemisphere, pharyngeal hot spots were combined and compared to sham using repeated measures ANOVA. Post hoc 1-way ANOVAs comparing each treatment to sham confirmed that rTMS to either cerebellar hemispheres significantly increased cortical excitability, which lasted up to 60 min ( p<0.05) and completely reversed the focal suppression induced by the virtual lesion. While there were no statistical hemispheric differences, contralesional cerebellar stimulation appeared to show visibly greater effects. By contrast, there were no effects directly seen on cerebellar excitability. <fig loc="float" id="F1"><no>Abstract PTH-126 Figure 1</no> <link locator="abs_2_F087"></fig> </sec> <sec><st>Conclusion</st> Ten Hz rTMS to either cerebellar hemisphere was able to reverse the inhibition provoked in pharyngeal motor cortex after a virtual lesion. Our data suggest that 10 Hz cerebellar rTMS may have a therapeutic role in recovery from dysphagia following brain injury, with the suggestion that stimulation to the contralesional cerebellum might have more sustained effects. </sec> <sec><st>Disclosure of Interest</st> None Declared </sec>
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Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».