PD20-03 FEMALE PERIURETHRAL TISSUE INNERVATION STUDIES: MID-URETHRAL SLING SURGERIES MAY RESULT IN SEXUAL DYSFUNCTION
Notice bibliographique
Résumé
You have accessJournal of UrologySexual Function/Dysfunction: Female (PD20)1 Apr 2019PD20-03 FEMALE PERIURETHRAL TISSUE INNERVATION STUDIES: MID-URETHRAL SLING SURGERIES MAY RESULT IN SEXUAL DYSFUNCTION Olivia Giovannetti, Madeline Monaghan, Johanna Hannan*, Barry Komisaruk, Sue Goldstein, Irwin Goldstein, and Michael Adams Olivia GiovannettiOlivia Giovannetti More articles by this author , Madeline MonaghanMadeline Monaghan More articles by this author , Johanna Hannan*Johanna Hannan* More articles by this author , Barry KomisarukBarry Komisaruk More articles by this author , Sue GoldsteinSue Goldstein More articles by this author , Irwin GoldsteinIrwin Goldstein More articles by this author , and Michael AdamsMichael Adams More articles by this author View All Author Informationhttps://doi.org/10.1097/01.JU.0000555735.67736.aaAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVES: The female periurethral tissue (FPT) contains numerous glands staining positive for prostate specific acid. These glands are surrounded by neuronal and vascular structures, and may have physiologic contribution to sexual function. The PFT is located adjacent to the anterior vaginal wall epithelium and surrounds the urethra passing distally from the bladder neck to the meatus. Decreased sexual function, especially lowered orgasm satisfaction has been reported following mid-urethral sling procedures to treat stress urinary incontinence, and requires further investigation of this possible iatrogenic effect. Cadaver studies have shown the mid-urethral sling transects through the glandular, neuronal, and vascular structures of the PFT. The goal of this new research is to further histologically characterize the PFT and examine patterns of innervation in relation to its specific morphological features. METHODS: Histologic and immunohistochemical investigations of glandular, vascular, and nervous structures of the FPT were examined from three fresh human female cadavers. The region of PFT examined was located in the same location of implanted mid-urethral slings. RESULTS: Positive staining for Anti-Nav 1.8 (sodium channel NaV 1.8), Anti-TH (tyrosine hydroxylase), and Anti-ChAT (choline acetyl transferase) indicated the presence of sensory, sympathetic, and parasympathetic innervation, respectively. The patterns of innervation of glandular and vascular structures varied depending on the type of innervation received. Nerve fibers were also located and stained positively for these three specific stains. Not all nerve subpopulations that stained positively for PGP9.5 were identified with the specific immunohistochemistry used in this investigation, and further immunohistochemistry is needed to stain for possible non-adrenergic non-cholinergic innervation. The qualitative analysis of serial tissue sections demonstrated multiple types of innervation of blood vessels and glandular tissue, and the existence of nerve fibers. CONCLUSIONS: The glandular, vascular, and neuronal structures of the FPT have multiple types of innervation consistent with a physiologic functioning organ, likely involved in female sexual response. Future studies will aim to: 1) further classify the subpopulations of nerves to correlate nerve type with female sexual responses, and 2) assess surgical modifications of mid-urethral sling placements to reduce risk of post-surgical sexual dysfunction. Source of Funding: None Kingston, Canada; Greenville, NC; Newark, NJ; San Diego, CA; Kingston, Canada© 2019 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 201Issue Supplement 4April 2019Page: e377-e378 Advertisement Copyright & Permissions© 2019 by American Urological Association Education and Research, Inc.MetricsAuthor Information Olivia Giovannetti More articles by this author Madeline Monaghan More articles by this author Johanna Hannan* More articles by this author Barry Komisaruk More articles by this author Sue Goldstein More articles by this author Irwin Goldstein More articles by this author Michael Adams More articles by this author Expand All Advertisement PDF downloadLoading ...
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,004 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,001 |
| Bibliométrie | 0,001 | 0,001 |
| Études des sciences et des technologies | 0,001 | 0,000 |
| Communication savante | 0,002 | 0,001 |
| Science ouverte | 0,001 | 0,001 |
| Intégrité de la recherche | 0,002 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,345 | 0,074 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».