OR25-4 Modulatory Effects of Estradiol on the Resting-State Functional Connectivity in Transwomen Following Gender Affirming Surgery
Notice bibliographique
Résumé
The profound incongruence between sex and gender identity leads transgender individuals to seek cross-sex hormone therapy (CSHT) and gender affirming surgery (GAS). After GAS, a transient period of hypogonadism is established. Literature suggests that sex hormones exert important effects on the brain during physiologic development and aging. Also, CSHT is known to impact brain anatomy and connectivity before the completion of GAS on transgender people. However, literature evaluating the brain impact of CSHT after GAS is still sparse. Here, we aimed to investigate the impact of CSHT on the resting-state functional connectivity (rs-FC) in transwomen (male-to-female) following GAS. Seed-based and data-driven approach were complementarily employed to explore rs-FC adaptations. To test for the effects of hypogonadism correction following CSHT, eighteen post-GAS transwomen underwent a 3T functional magnetic resonance imaging (fMRI) at two time points: 30 days after CSHT washout, and 60 days following estradiol reinstitution (CSHT). Anxiety assessment and blood sample collection were conducted at both time points. First, region-of-interest to region-of-interest (ROI-to-ROI) rs-FC was explored using Principal Component Analysis. Bilateral thalamus and right caudate were defined as seeds, while the sensorimotor cortex (SMC) was defined as target, according to previous literature1,2. Rs-FC was compared between time points using a paired t-test. Additionally, a whole-brain data-driven approach using multivoxel pattern analysis (MVPA) was performed to generate a seed for further whole-brain seed-to-voxel analysis. All analyses were thresholded at p < 0.05 (two-tailed), controlled for age and anxiety changes between time points and FDR corrected for multiple comparisons. Following estradiol therapy, we found higher rs-FC between left thalamus and the bilateral SMC (p-FDRLeft=0.0027; p-FDRRight=0.0196). MPVA analysis identified a cluster within the subcallosal cortex (SubCalC) representing the greatest variability in functional activation between time-points (p[FDRcorr]=0.0017; size=91 voxels). Lastly, whole-brain seed-to-voxel analysis using the SubCalC as seed pointed out for a rs-FC decoupling between SubCalC and a region within the middle frontal cortex (p[FDRcorr]= 0.001; size= 313 voxels). In conclusion, estradiol seems to modulate rs-FC in regions engaged in cognitive2,3, emotional4 and sensorimotor processes2 in transwomen following GAS. This phenomenon highlights rs-FC adaptations due to hypogonadism correction and helps to understand cognitive and emotional regulation changes occurring during hormonal adjustment. Reference: 1-Nota et al., Psychoneuroendocrinology. 2017; 86,187-195 2-Kenna et al., Neurochem Res. 2008; 34, 234-237. 3-De Simoni et al., Brain. 2017; 141, 148-164. 4- Dunlop et al., Am J Psychiatry. 2018; 174, 533-545. Support: CNPq
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Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,001 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».