Parenteral nutrition as a risk factor for bronchopulmonary dysplasia: its role and possible mechanisms in infants less than 29 weeks gestation
Notice bibliographique
Résumé
One of the most devastating prematurity complications is bronchopulmonary dysplasia (BPD). BPD etiology is multifactorial and one major factor is early oxidative stress due to high oxygen exposure. The relationship between non-radical oxidative stress (redox stress) caused by the peroxides contaminating the parenteral nutrition (PN) and BPD is less studied. Studies applying complete photoprotection of PN, which can decrease the peroxide contamination of PN by half, decreased BPD by 25-30%. A correlation between the redox potential on day 7 of life and BPD severity was demonstrated in preterm infants. Hypothesis and objectives: Hypothesis: Peroxides contaminating PN lead to prolonged redox stress and contribute to the development of BPD. This effect is due to deficient detoxification of peroxides. Objectives: - To study the post PN redox stress duration and its impact on BPD in relation to other oxidants (O2, infection, blood transfusion) - To test if the deficient peroxides’ detoxification is related to glutathione deficiency - To evaluate first week urinary ascorbylperoxide concentration as a BPD biomarker Patients and methods: One hundred sixteen infants < 29 weeks of gestation were followed until 36 weeks postmenstrual age (PMA). Fifty-one families gave consent for urine and blood samples. The first objective was achieved by measuring total blood reduced (GSH) and disulfide (GSSG) glutathione at 36 weeks PMA using capillary electrophoresis to calculate the redox potential using Nernst equation. For the second objective, total plasma glutathione, red blood cell glutathione reductase (GR) and peroxidase (GPx) activities were measured on day 7 of life. The third objective was achieved by measuring ascorbylperoxide (AscOOH) in the urine on days 3, 5 and 7 of life. Chi-square, t-student, ANOVA, linear regression and repeated measure ANOVA were used as appropriate; p< 0.05 was significant. Results: PN duration > 14 days was associated with more oxidized redox potential (-193±5 versus -203±2 mV) and more BPD (89% versus 24%). FiO2 ≥ 25% on day 7 of life was also associated with a more oxidized redox potential (-191±2 versus -198 ±2 mV) and more BPD (90% versus 45%). The effects of PN and FiO2 on redox potential and BPD were additive. In logistic regression model, each 1% increase in FiO2 and each day increase on PN resulted in an increase in the OR for BPD by1.57 (1.09 - 2.28) and 1.17 (1.03 - 1.33) respectively. Compared to normal values, total plasma glutathione concentration was low (1.02, 0.49-1.76 µmol/l: median, 25th –75th percentiles) whereas GPx and GR activities were sufficient. Urinary AscOOH increased overtime (p=0.001) and was higher in infants who later developed BPD or death (p=0.037). Conclusion: Early O2 and peroxides contaminating PN have additive effects associated with prolonged oxidative stress and increased BPD. Extremely preterm infants have low glutathione level that limits their capacity to detoxify peroxides. Higher first week urinary AscOOH levels are associated with increased BPD or death. Judicious use of oxygen decreasing the duration or developing a safer formulation of PN and GSH replacement therapy should be investigated as strategies to decrease BPD in extremely preterm infants.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,002 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,001 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,001 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,001 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,003 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».