Identification of Demographic and Clinical Characteristics, Differentially Expressed Genes, and Differentially Perturbed Pathways Associated with Chemotherapy-Induced Nausea
Notice bibliographique
Résumé
Despite advancements in antiemetic prophylaxis, chemotherapy-induced nausea (CIN) continues to be a significant clinical problem. Between 30% to 60% of oncology patients experience CIN. While a number of demographic and clinical characteristics are established risk factors CIN, these phenotype risk factors do not explain all of the variance in the occurrence of CIN. The purposes of this dissertation research were to: perform a systematic review of the literature on the associations between single nucleotide polymorphisms (SNPs) in candidate genes and the occurrence of CIN; determine additional risk factors associated with the occurrence of CIN; and determine additional molecular mechanisms associated with the occurrence of CIN. Sixteen studies evaluated for associations between genomic markers and the occurrence and/or severity of chemotherapy-induced nausea and vomiting (CINV). Candidate genes in the major mechanistic pathways for CINV (i.e., serotonin receptor pathway, drug transport pathway and/or drug metabolism) were evaluated for associations with the occurrence and severity of CINV. In brief, none of the SNPs in these mechanistic pathways were associated with CIN occurrence. Demographic and clinical risk factors were evaluated for their associations with CIN occurrence. In addition, the impact of concurrent symptoms, stress associated with cancer and its treatment, as well as quality of life (QOL) outcomes on the occurrence of CIN were investigated in patients prior to their next dose of chemotherapy (CTX). Modifiable risk factors identified in this study include: having child-care responsibilities; poorer functional status; and higher levels of depression, sleep disturbance, evening fatigue, perceived stress, and intrusive thoughts and feelings. Patients who reported CIN experienced decrements in QOL outcomes.Because findings regarding associations between mechanistically-based candidate genes and CIN occurrence were inconclusive, a hypothesis-generating study was undertaken to uncover novel mechanisms associated with CIN occurrence. Findings from this dissertation research suggest that a number of differentially expressed genes and perturbed pathways in the gut-brain axis are associated with the occurrence of CIN. CTX-induced changes in the GBA that may contribute to the occurrence of CIN include: mucosal inflammation and disruption of the gut microbiome. This dissertation concludes with implications for clinical practice and directions for future research.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,001 | 0,001 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».