Effect of Maternal Vitamin D Supplementation During Pregnancy and Lactation on Early Infant Nasal Pneumococcal Carriage in Bangladesh (P10-125-19)
Notice bibliographique
Résumé
To estimate the dose-dependent effects of maternal vitamin D3 (VD) supplementation during pregnancy and lactation on the risk of first nasal pneumococcal colonization (PnC) and the dynamics of nasal pneumococcal (Pn) carriage in infants from birth to 6 months (mos) of age in Dhaka, Bangladesh. Infants born to mothers who received weekly VD doses in one of 4 pre/post-partum dose combinations or placebo as part of the Maternal Vitamin D Supplementation during Pregnancy and Lactation to Prevent Acute Respiratory Illness (MDARI) study, were monitored from 0–6 mos for signs of an acute respiratory infection (ARI). A nasal swab was performed to obtain a sample of nasal epithelial tissue if the infant met pre-set ARI criteria. Nasal PnC was detected by qPCR. The effect of VD on the risk of first observed PnC was estimated by an interval-censored survival model. A multi-state model was used to characterize the dynamics of Pn carriage using transition probabilities of state changes. Of 1060 infants in MDARI, PnC was observed in 90% during the first 6 mos of life with 69% of swabs being positive (n = 3792). There was no significant difference between any VD group and placebo on the risk of initial nasal PnC (Table 1). Overall, the predicted median time to colonization was 7 weeks. Transitioning between positive and negative episodes was common: among 949 infants who were ever positive, 238 (25%) were observed to revert to negative during the first 6 mos of life, of whom 99 (40%) had at least one additional positive swab. Across all groups, an infant was predicted to spend 69 days negative and 120 days positive during the first 6 mos; yet, no Pn dynamics differed significantly across treatment groups (P >0.05). PnC and Pn dynamics were associated with season of birth, parental education and number of siblings, but were not associated with infant characteristics including anthropometric parameters. These results do not provide evidence supporting an effect of VD on infants’ risk of first nasal PnC nor the dynamics of carriage in a setting where early infant PnC is highly probable. In contrast to in vitro data that demonstrated that VD promoted immune responses against pneumococcus, the present study does not support the hypothesis that improvements in VD status in early infancy reduces the risk of Pn colonization. Bill & Melinda Gates Foundation.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».