Abstract 659: Expression patterns of NF-κB in inflammatory oral potentially malignant lesions
Notice bibliographique
Résumé
Introduction: Oral lichen planus (OLP), a common chronic autoimmune inflammatory condition, is recognized as a potentially malignant condition by the World Health Organization. However, some argue that only OLP with epithelial dysplasia - termed lichenoid dysplasia (LD) - have malignant potential. As research continues to characterize the immune microenvironment of OLP, there is a need to elucidate factors favorable for malignant change. Recent research has demonstrated that activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) is key to cancer development. This transcription factor has been extensively explored in inflammation-associated cancers, such as colon and gastric cancers. There is a need to investigate these factors in oral potentially malignant lesions (OPML), including OPL. In this study, we aim to compare clinical and risk habit differences between OLP and LD, and determine if NF-κB expression is associated with histological and clinical features of OPML indicative of cancer risk.Methods: Clinical, demographic, and histological data have been collected from the Oral Cancer Prediction Longitudinal (OCPL) study and the CoPath Vancouver Coastal Health Database. Patients with a primary diagnosis of OLP or low-grade LD were eligible to participate. Patients with previous history of head and neck cancer, or who have less than one year of follow-up are excluded from enrollment. Demographic, risk habit and clinical information was collected.For completed cases, immunohistochemistry (IHC) has been performed on formalin-fixed and paraffin-embedded tissue. Nuclear reactivity of NF-κB in the epithelium was counted in 10 high-power fields, and cytoplasmic positivity classified into 4 categories. Chi-squared tests were performed on categorical demographic and risk habit data.Results: To date, 51 participants have been recruited into this ongoing study: 37 with OLP and 14 cases of LD. There is no significant difference in gender and age between groups (p=0.297, p=0.120, respectively). Ever smokers and lesion location at a high-risk site were significantly associated with a diagnosis of LD compared to OLP (p=0.002, p<0.001, respectively). Preliminary IHC results show strong NF-κB positivity in the sub-epithelial lymphocytic infiltrate and strong to moderate cytoplasmic reactivity in the epithelium. Nuclear reactivity appears to increase from lichen planus to dysplasia.Conclusion: Patients with LD were more apt to be smokers, and more often presented with lesions at a high-risk site compared to those with OLP. Strong NF‐κB cytoplasmic positivity in OLP, especially adjacent to areas with intense cytotoxic inflammatory infiltrate, reinforces the prominent role of NF-κB in inflammation.Citation Format: Iris Lin, Lewei Zhang, Miriam Rosin, Leigha Rock, Denise Laronde. Expression patterns of NF-κB in inflammatory oral potentially malignant lesions [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 659.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,001 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».