The Epidemiology of Late-Onset Inflammatory Bowel Disease
Notice bibliographique
Résumé
Introduction: Inflammatory bowel disease (IBD) is a condition more commonly diagnosed in a younger population. There is evolving evidence that both Crohn's disease (CD) and ulcerative colitis (UC) are increasingly being diagnosed in older patients. Despite this, there has been little discussion on the comparative epidemiology of these two populations. Methods: Patients were selected at random from a list of those billed for diagnosis codes attributed to IBD. Of our initial list of 1006 patients, we excluded 345 patients who were inappropriately coded as having IBD. We then excluded 14 patients who did not have a known age of diagnosis leaving a final list of 648 patients. We separated our list into three cohorts: those diagnosed with IBD before the age of 45, but who are currently younger than 45 (Group 1); those diagnosed before the age of 45, but who are currently older than 45 (Group 2); and those diagnosed after the age of 45 (Group 3). Chi-squared tests were used for statistical analysis. Results: Of the 648 patients, 293 were in Group 1, 177 in Group 2, and 178 in Group 3. The average age of diagnosis for the three groups was 31.3, 31.1, and 56.5 years old respectively. Across the groups there was no statistical difference in gender and percent of patients reporting having a family history of IBD. There was a significant difference for what type of IBD was diagnosed across the three groups. In Group 1 63% of patients were diagnosed with CD, in Group 2 57% were diagnosed with CD, and in Group 3 44% were diagnosed with CD (p < 0.05). For those patients diagnosed with CD there was a trend towards a significant difference in the Montreal Classification across the three groups (p=0.06. For those with UC there was no significant difference in the extent of disease among the three groups. There was a significant difference among the groups for the frequency of patients requiring surgery (Group 1 36%, Group 2 44%, and Group 3 22%; p < 0.05). Finally, there was also a significant difference in the percent of patients with a history of smoking across the three groups (Group 1 29.6%, Group 2 41.8%, and Group 3 53.4% (p < 0.05). Conclusion: While there are similarities among patients who are diagnosed with IBD before and after the age of 45, there are some significant differences as well. These differences may provide an opportunity to better understand how the pathogenesis of IBD changes as our patients get older.Figure 1
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,003 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,001 | 0,002 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,001 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,002 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».