Effect of Antidepressants on Sleep in Functional Dyspepsia
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Notice bibliographique
Résumé
Introduction: Individuals with functional dyspepsia (FD) frequently report non-gastrointestinal symptoms. Little is known about sleep quality in those with FD. Aim: To evaluate changes in sleep quality in response to antidepressant therapy in FD patients. Methods: The Functional Dyspepsia Treatment Trial (FDTT) was a 12-week, multi-center, randomized, double blind, placebo-controlled trial evaluating antidepressants in FD. Subjects meeting Rome II criteria were randomized to placebo (PLA), 50 mg amitriptyline (AMI), or 10 mg escitalopram (ESC), were excluded if receiving antidepressant or psychotropic medication, had current drug/alcohol abuse, or scored ≥11 on the Hospital Anxiety Depression Scale (HADS). A Pittsburgh Sleep Quality Index (PSQI) was completed at baseline and after treatment. The association of baseline values with treatment group was assessed using the Kruskal-Wallis test. An ITT ANCOVA (based on ranks) using baseline and balancing factors as covariates was used to assess post-treatment effects. Treatment effects on changes in PSQI scores were also assessed using the Kruskal-Wallis test. Results: 292 subjects were randomized: mean age was 44, 219 (75%) were female. Baseline and posttreatment PSQI data were available from 261 (89%) and 185 (63%) individuals. Baseline mean global scores across the group indicated poor sleep quality (mean scores >5) in all treatment arms. The worst subscore was seen for Sleep Efficiency with an overall mean of 3.0 (SE 0.01) in all three arms. After treatment, Global Sleep and Sleep Efficiency scores remained poor across the three treatment arms. Overall treatment effects on Sleep Duration scores were observed (p=0.019) with lower (better) scores in the AMI arm compared to the PLA and ESC arms, but the change from baseline did not differ significantly among the treatment arms. Post-treatment scores for Sleep Quality, Sleep Latency, Sleep Efficiency, Sleep Disturbance, Sleep Medication, Daytime Dysfunction did not differ among treatment arms. There were overall borderline treatment effects on changes in Sleep Quality (p=0.05) with improved sleep (decreased scores) in the PLA arm compared to the antidepressant arms. Conclusion: Individuals with FD commonly report poor sleep quality. Sleep duration scores were better in those receiving amitriptyline, suggesting that a potential benefit of amitriptyline is improved length of sleep; however, its effects on sleep quality are otherwise modest at best.Table 1
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Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,006 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,001 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découle