Evaluation of Processing Software for SPECT Myocardial Blood Flow
Notice bibliographique
Résumé
168 Objectives: Stationary cardiac SPECT cameras have greatly simplified the acquisition of dynamic datasets and led to a renewed interest in measuring myocardial blood flow (MBF) with SPECT. Several single-center studies have shown that it is feasible with these cameras and standard myocardial perfusion tracers to accurately measure MBF. MBF data have the potential to identify multi-vessel disease and thus improve risk stratification of patients with coronary artery disease. Clinical use of SPECT MBF will require commercial software for flow processing on the camera workstation. In this study we evaluate the accuracy, intra- and inter-user variability of a recently released software package for SPECT MBF analysis. Methods: The SPECT MBF component of 4DM (v2017, Invia) was compared to PET using a retrospective analysis of 31 patients for whom both SPECT MBF and standard clinical PET MBF studies were acquired within one month. SPECT data were acquired on a multi-pinhole stationary cardiac camera (GE Healthcare) with Tc-99m-tetrofosmin using a rest/stress one-day protocol. Listmode data were obtained starting at injection and continuing for 11min. Vendor online software was used to re-frame data into 9 x 10 s, 6 x 15 s, and 4 x 120 s time frames which were then reconstructed using an iterative algorithm with noise regularization (MAP-EM). The CT from the PET/CT scan was imported and manually co-registered the emission image for attenuation correction (AC). The dynamic image series was imported into 4DM (v2017, Invia) for analysis. Manual motion correction (MC) was applied frame-by-frame to visually align with a late-frame contour of the myocardial uptake. The arterial input function was obtained with a region of interest centered axially on the base of the septum. A 1-tissue compartment model was applied to determine the uptake constant K1. Image processing was performed independently by two users with repeat evaluation by one user to estimate inter- and intra-user variability. Global left-ventricular K1 values were averaged between users and fit to PET MBF values using a repeated two-fold cross-validation approach to estimate parameters of the Renkin-Crone extraction fraction correction for converting K1 to MBF. Images reconstructed with no corrections (NC), AC, MC, and ACMC were considered. Results: There was good correlation between K1 and PET MBF (R2 = 0.57 to 0.71). The extraction-fraction function parameters were found to be different than those determined previously with off-line software but the resulting MBF values were similar. The standard deviation of the percent difference of the 4DM MBF from PET MBF was between 43% (NC) and 33% (ACMC). The mean inter-user difference was 8% ± 18% (NC) and 4% ± 16% (ACMC). The mean intra-user difference was 6% ± 19% (NC) and 2% ± 16% (ACMC). Conclusions: Correlation and standard deviation in the flow difference from PET were similar to those obtained previously with in-house software. The extraction fraction parameters differed from those found previously suggesting that some cross-calibration may be needed between software packages. Inter- and intra-user differences were small compared to overall uncertainty.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,009 | 0,022 |
| Méta-épidémiologie (sens strict) | 0,001 | 0,001 |
| Méta-épidémiologie (sens large) | 0,001 | 0,001 |
| Bibliométrie | 0,002 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,001 | 0,001 |
| Science ouverte | 0,001 | 0,001 |
| Intégrité de la recherche | 0,000 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,011 | 0,003 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».