DYNAMICS OF INDICATORS OF ARTERIAL PRESSURE REGULATION AND THEIR DEPENDENCE ON THE LEVELS OF GALECTIN-3 AND ALDOSTERON IN PATIENTS WITH ESSENTIAL HYPERTENSION

This article presents the analysis of the nature of daily blood pressure regulation according to findings of 24-hour monitoring, depending on the levels of two neurohormones, galectin-3 and aldosterone, in the plasma of patients with essential hypertension. Material and methods. According to this goal, the study included 119 (74.4%) patients aged 19-60 years. The diagnosis of essential hypertension was confirmed on the basis of current valid criteria. Each patient underwent a procedure of daily blood pressure monitoring using the apparatus "AVRM-04" Meditech (Hungary). Results and discussion. Aldosterone level was determined by the enzyme-linked immunosorbent assay ELISA using reagents of IBL International GmbH (Canada). The level of galectin-3 in serum was determined by the solid-phase enzyme linked immunosorbent assay using a set of reagents of Human Galectin-3 Platinum ELISA (Bender MedSystems GmbH, Austria). By variation statistics, three plasma levels of galectin-3 were isolated in the main group of patients: the first level was relatively low (<1.1 pg / ml), the second was relatively moderate (from 1.1 to 2, 4 pg / ml) and the third was relatively high level (> 2.4 pg / ml). However, the levels for aldosterone were respectively: the first was relatively low (<206 pg / ml), the second was relatively moderate (from 206 to 325 pg / ml), and the third was relatively high (> 325 pg) / ml). Statistical processing of the findings was processes by additional standard methods from the StatSoft "Statistica" software package V. 12.0. We have found out that in the patients of young and middle age with essential hypertension stage II, the levels of galectin-3 and aldosterone significantly affected the daily regulation of blood pressure. The young and middle-aged patients has relatively high and relatively moderate plasma levels of galectin-3, which can be associated with a significant increase in the heart rate during the day and the heart rate during the night; 24-hour systolic blood pressure (BP), day systolic BP and night systolic BP, 24-hour diastolic BP, day diastolic BP and night diastolic BP, mean PB during the day and mean BP during the night; 24-hour pressure index, pressure index during the day and pressure index during the night; variability of systolic BP during the night, variability of 24-hour diastolic BP, variability of systolic BP during the night; with a decrease in circadian index and 24-hour diastolic BP index; with an increase in the incidence of non-dipper pathological profile registration and a decrease in physiological dipper by changes in both systolic blood pressure and diastolic blood pressure. Conclusion. Aldosterone levels, especially relatively high and relatively moderate, compared to relatively low, are associated with a significant increase in daytime and night time heart rate, 24-hour systolic BP, day and night, 24-hour diastolic BP, and during the night, 24-hour mean BP, as well as during the day and during the night, 24-hour pressure index, as well as pressure index during the day and the night, systolic BP variability at the night, rate of early systolic and diastolic BP rise and decrease in 24-hour systolic and diastolic BP index; with increasing rate of registration of pathological profile “non-dipper” and decrease in “over-dipper” with changes in systolic BP; an increase in the incidence of non-dipper pathological profile registration and a decrease in the normal dipper profile according to diastolic BP. The authors of this study confirm that the research and publication of the results were not associated with any conflicts regarding commercial or financial relations, relations with organizations and/or individuals who may have been related to the study, and interrelations of co-authors of the article.

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