Metastatic Peripheral Neuroblastoma in a Dog
Notice bibliographique
Résumé
Background: Peripheral neuroblast neoplasms are considered as a group of tumors derived from primitive cells of the neural crest that are progenitors of the sympathetic ganglia and adrenal medulla. Reports of neuroblastoma in dogs are scarce in English literature, and there are no reports from Brazil due to its rare occurrence or missed diagnosis, because modern techniques are often not accessible in Brazil. The aim of the present study was reported a case of metastatic peripheral neuroblastoma in a 10-month-old bitch of Canadian Shepherd breed, attended at the Small Animal Veterinary Hospital of the Federal Rural University of Rio de Janeiro (HVPA-UFRRJ).Case: A 10-month-old female dog, Canadian Shepherd breed, presenting prostration, inappetence, emesis, progressive weight loss, and difficulties in the locomotion of the pelvic limbs was brought to the Small Animal Veterinary Hospital of the Federal Rural University of Rio de Janeiro (HVPA / UFRRJ) for treatment. Palpation of the abdominal cavity revealed a mass of approximately 14.0 cm diameter in the thoracolumbar region. After the second visit to HVPA/ UFRRJ, there was worsening of the clinical condition and onset of pain and dyspnea; hence, euthanasia was performed. The dog was referred for necropsy; the examination revealed a mass measuring 40.0 × 35.0 cm in the abdominal cavity that caused displacement of the intestines and compressed the liver against the diaphragm, as well as another mass that traversed the diaphragm through the esophageal hiatus and surrounded the esophagus, aorta, and caudal vena cava. The right adrenal gland was compressed and adhered to the mass, and the left adrenal gland was not visualized. Specimens of various organs were collected, fixed in 10% buffered formalin, and processed according to routine histological technique. Immunohistochemical examination performed on mass specimens revealed positivity for the anti-CD56, anti-synaptophysin, anti-GFAP, and anti-NSE markers and negativity for the anti-chromogranin and anti-Olig2 markers. Based on pathology and immunohistochemistry findings, a diagnosis of poorly differentiated peripheral neuroblastoma was made; in addition, presence of emboli of neoplastic cells in the hepatic sinusoids and branches of the portal vein and metastasis in the spleen, lymph nodes, lung, and meninges were confirmed.Discussion: Positive results for neural markers associated with negative results for those of other small round cell tumors was considered to indicate the presence of neuroblast tumors; glioblastoma and oligodendroglioma were ruled out based on the absence of anti-Olig2 labeling, and, especially, the possibility of occurrence of pheochromocytoma was excluded based on the absence of anti-chromogranin. During necropsy, the location of the mass at the retroperitoneal space near the thoracolumbar junction, craniomedially in relation to the left kidney, was confirmed, which is compatible with the location of the adrenal gland. Metastasis in the dura mater was determined to be present based on necropsy findings alone, and neoplastic invasion through the esophageal hiatus of the diaphragm of a large part of the thoracic cavity was observed, which, to the best of our knowledge, have not been described in reports of veterinary medicine. The high rate of tumor growth and compression and invasion of adjacent tissues and organs may be considered as potential factors for unfavorable prognosis of peripheral neuroblastoma.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,002 | 0,001 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; les deux têtes enseignantes s’accordent sur ce qui est montré ici.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».