Dandelion Root and Chronic Myelomonocytic Leukemia
Notice bibliographique
Résumé
Abstract Case 1 70 year old man presented with acute myelo-monocytic leukemia diagnosed in June 2009. He demonstrated no response to standard 7+3, nor high dose AraC. He remains in remission from his acute leukemia 4 years from his diagnosis, as long has he remains on the dandelion root tea, which was started immediately after chemotherapy. If he takes less than three cups / day of the DRT, his peripheral blood monocytes start to rise.1 Repeat testing demonstrates chronic myelomonocytic leukemia. Case 2 Sixty year old female with acute myelomonoctyic leukemia possibly progressing from chronic myelomonocytic leukemia. She underwent induction chemotherapy with 7+3. Her day 28 marrow showed no evidence of remission. She then underwent re-induction with high dose Ara-C at 3 gm/ m2 x 6 doses. She did receive neupogen support, and on day 28, her peripheral blood white blood count was 60 x 109/L with monocytes of 3.0 x 109/L and blasts 1.2 x 109/L. Repeat bone marrow biopsy identified chronic myelomonocytic leukemia (CMML). She stopped the neupogen and started dandelion root tea, three cups per day. She is now 5 months from her initial diagnosis and remains in complete hematological response: WBC 4.2/ Hgb 127 / Platelet 182/ Neutophils 2.6 / Monocytes 0.8. Other Cases We have had other possible cases that may support the efficacy of this product in refractory hematological malignancies. In one case of CMML-2 a 76 year old man did receive azacytadine for the duration of his treatment, as well as DRT. He finally succumbed to his disease at 30 months after his diagnosis. We previously presented an elderly female that used only DRT to treat her CMML and experienced a hematological remission for 3 months prior to relapse. Her initial WBC was 130,000 x 109/L.3 Another case of acute myeloid leukemia, who, because of co-morbidities was not a candidate for more aggressive options, relapsed from her M2- acute myeloid leukemia in November 2010. She was treated with low dose AraC, and then dandelion root tea. Although she remained transfusion dependent, she only developed peripheral blasts when she was unable to find the DRT for one month. She continues on the DRT at 15 month from relapse of her acute leukemia.3 We have a phase 1 clinical trial open at our centre investigating a novel formulation of dandelion root extract in refractory hematological malignancies. We plan to study the molecular pathways previously described in CMML including TET2 , CBL , NRAS, KRAS, JAK2 and RUNX1. http://www.ontario.canadiancancertrials.ca/trial/Default.aspx?dsEndecaNav=Ro%3A0%2CNs%3AP_TrialStatus_sort_en%7C101%7C-1%7C%2CNrc%3Aid-30-dynrank-disabled%7Cid-130-dynrank-disabled%7Cid-131-dynrank-disabled%7Cid-132-dynrank-disabled%7Cid-619-dynrank-disabled%7Cid-620-dynrank-disabled%7Cid-621-dynrank-disabled%7Cid-622-dynrank-disabled%7Cid-4294965875-dynrank-disabled%2CN%3A4294952782&TrialId=OCT1226&lang=en 1 Caroline Hamm and Sindu M. Kanjeekal, Unusual Response of Acute Monocytic Leukemia to Dandelion Root Extract, Blood (ASH Annual Meeting Abstracts), Nov 2011; 118: 4288 2. Kohlmann A, Grossmann V, et al. Next Generation Sequencing of Technology Reveals a Characteristic Pattern of Molecular Mutations in 72.8% of Chronic Myelomonocytic Leukemia by Detecting Frequent alterations in TET2, CBL, RAS, and RUNX1. JCO (28) 2009. 3. Ng W, Hamm C. Can Dandelions Cure? Schulich School of Medicine Research Day, 2009 Disclosures: No relevant conflicts of interest to declare.
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Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,001 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,001 | 0,001 |
| Études des sciences et des technologies | 0,001 | 0,001 |
| Communication savante | 0,001 | 0,001 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,002 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,005 | 0,001 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».