Editorial: Back to the Future: On the Road Towards Precision Psychiatry
Notice bibliographique
Résumé
On the Road Towards Precision PsychiatryPsychiatry, with the field of Precision Psychiatry, has been experiencing one of the most exciting moments of its history with a paradigmatic shift (1).A few years ago, it became clear that the understanding of psychiatry at the time, mostly descriptive and phenomenologically based, was wanting.This led to a crisis within the psychiatric community, and, some would say, a disbelief in the field; the simply phenomenologically driven paradigm of the time was no longer sufficient.According to philosophy of science, when a paradigm is threatened by crisis, the community itself, in this case, the psychiatric community, with its clinicians and scientists, is in disarray.For instance, there are moving quotations from Wolfgang Pauli, one a few months before Heisenberg's matrix algebra, which was a major conceptual change in quantum mechanics, and one just some months after.In the former, Pauli expresses the feeling that physics is going to ruin, and he wishes he were in another field; a few months later, the way ahead is clear.At the time, many had the same feeling, and at the height of the crisis, the community was falling apart as the current paradigm was under questioning (2).Crisis and paradigm change go hand in hand; however, crisis does not, in itself, lead to rejection of the existing paradigm.The decision to reject one paradigm is invariable parallel to the decision to accept another, and the logic leading to that decision involves the comparison of both paradigms with each other.In this sense, precision psychiatry, by embracing the heterogeneity of psychiatric disorders, and thus aiming at predicting diagnosis, prognosis, and response to treatment for an unique individual by employing the underlying pathophysiology, as opposed to diagnosing and treating psychiatric disorders merely informed by the somehow subjective clinical characteristics of a patient, constitutes a new paradigm in psychiatry (1).A new paradigm is always accompanied by exciting new research, and the psychiatric scientific community is becoming fully committed to embracing Precision Psychiatry by actively conducting very high-quality science in the field.By presenting findings from previously separate fields of psychiatry, neurophysiology, and computational modelling, with the Research Topic "Back to the Future: On the Road Towards Precision Psychiatry," we were able to contribute to the advancement and to promote this new field.Precision Medicine has been defined as 'an emerging approach for treatment and prevention that takes into account each person's variability in genes, environment, and lifestyle' (3).In this Research Topic, research regarding biomarkers and the biosignature of psychiatric disorders was advanced.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,008 | 0,031 |
| Méta-épidémiologie (sens strict) | 0,004 | 0,001 |
| Méta-épidémiologie (sens large) | 0,004 | 0,002 |
| Bibliométrie | 0,004 | 0,002 |
| Études des sciences et des technologies | 0,005 | 0,003 |
| Communication savante | 0,009 | 0,006 |
| Science ouverte | 0,004 | 0,002 |
| Intégrité de la recherche | 0,016 | 0,018 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,030 | 0,026 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».