A258 ASSOCIATION BETWEEN SYMPTOMS AND INFLAMMATORY BOWEL DISEASE ACTIVITY USING INFLAMMATORY BOWEL DISEASE SYMPTOM INVENTORY – A RETROSPECTIVE ANALYSIS FROM THE MANITOBA LIVING WITH IBD STUDY
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Notice bibliographique
Résumé
Abstract Background Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gut and includes predominantly Crohn’s disease (CD) and ulcerative colitis (UC). The Inflammatory Bowel Disease Symptom Inventory (IBDSI), developed at the University of Manitoba is a validated patient self-report symptom inventory which has shown to demonstrate good validity to accepted clinician-based assessments of disease activity. The IBDSI focuses of 5 main symptom clusters: bowel symptoms, abdominal discomfort, fatigue, bowel complications, and systemic complications. While there is good evidence for the presence of these symptoms in IBD, there has yet to be an analysis of the correlation between specific symptom clusters and active IBD. Aims Our aim is to identify symptoms experienced by patients with IBD being followed prospectively over one year and further analyze which of these symptoms are correlated with disease activity. Methods 155 patients enrolled in the Manitoba Living with IBD Study were eligible for the current study. Bi-weekly IBDSI short-form survey results were analyzed to determine which IBD-related symptoms were experienced by each patient over the study period (1 year). Descriptive data for symptoms will be reported, and will then be compared to disease activity (defined in Crohn’s disease as an IBDSI score >14 and in UC>13 and fecal calprotectin level (FCAL) >250 ug/g) to determine which symptoms most correlate with active IBD. Results The study population ranged from ages 18–70, with a mean age of 43 years. 30.3% (47) of the population were male. 65.8% (102) of the population consisted of CD, 31.0% (48) had UC, the remaining 3.2% (5) had IBD-type unclassified. Some of the symptoms for analysis will include abdominal pain, frequency and consistency of bowel movements, blood within the stool, and other associated symptoms such as nausea and loss of appetite. The results for the frequency of symptoms reported and which are most correlated with disease activity is still under analysis. Conclusions This will be the first study assessing the association between symptoms experienced by subjects contrasted to disease activity using the self-reported measurement IBDSI and FCAL. Funding Agencies None
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Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,002 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découle