Hypoglycaemic Activity and Biochemical Effects of Cataranthusroseus with Diabenese in Normal and Diabet IC Rats
Notice bibliographique
Résumé
INTRODUCTIONDiabetes mellitus is a chronic endocrinologic disorder characterized by high blood glucose levels arising from insufficient secretion of insulin by the pancreas or improper utilization by target cells.Diabetes is the most common endocrinologic disorder with widespread prevalence cutting across all populations groups (Report of the expert committee on Diagnosis and classification of diabetes mellitus, 1998).The insufficient secretion of insulin by pancreatic islet calls or detective insulin receptors.Leads to poor utilization of insulin by target cells culminating in raised fasting blood glucose levels (>8mmoi/L) glycosylated haemoglobin (Hb A/C) greater than 6 -9%.Glycosylated haemoglobin gives and indication of average blood glucose concentration over a 6 -8 week period and is a biochemical test used for monitoring progression of diabetes or response to treatment.While the capillary or a venous glucose valve gives the blood glucose levels.Besides the immediate perceptible metabolic disfunction accompanying hyperglycemia.There are longterm complication of diabetes mellitus involving disorders of the eyes, kidneys, nerves and blood vessels.The Canadian Diabetes Association (2003), reported three main types diabetes: Type 1 diabetes usually diagnosed in children and adolescence which occurs when the pancreas is unable to produce insulin necessary to meets the energy needs of tissues required in the body.About 10 percent of people with diabetes have type I diabetes.It is also called insulin dependent Diabetes.The remaining 90 percent of diabetes have type II diabetes that occurs when the pancreas does not produce enough insulin or body does not effectively use insulin that is produce and is developed in adulthood.A third type, gestational diabetes which is a temporary condition, occurs during pregnancy.It affects 3.55 percent of all pregnancies and present an increased risk of developing diabetes for both mother and child in later life (Mayfield 1998; Canadian diabetes association 2003).According to Clavell (2002) report on Diabetes Management as documental by the Mayo foundation for Medical Education and Research in New York identified a forth type of diabetes arising from illness or medications that can interface with production of insulin or its action.Approximately 1-2% of all diagnosed cases belongs to this group and include inflammation of the pancreases, pancreatomy, adrenal or pituitary disorders hydrocortisones treatments for another disease, some high blood pressure and Cholesterol lowering medications malnutrition and infection.Diabetes is a syndrome of disturbed intermediary metabolism diabetes mellitus commonly concomitant with hypertension and other disease (Greff, 2000).It is therefore not a single disease entity but has been described to be a syndrome characterized by an absolute or relative lack of insulin Abstract: The hypoglycaemic activity and biochemical effects of cataranthusroseus with diabenese in normal and diabetic rats were compared.Ethanollic extract of C. roseus were screened for their phytochemical constituents using standard methods.Biochemical effects were evaluated on alloxan induced diabetic rat (32) assigned into four study groups of eight rats each Group 1 (control) received diabinse (14.28mg/kg).C roseus (400mg/kg) all in 30% ethanol.At the end of 21 day administration period blood serum was obtained from sacrificed animals and biochemical indices of toxicity (lipid profile, aminotransferases activity, serum protein, urea and albumin.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,001 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,001 |
| Bibliométrie | 0,001 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,002 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».