Commentary: Venoarterial extracorporeal membrane oxygenation, ventricular dysfunction, and a mitral valve prosthesis: A recipe for valve thrombosis?

Central MessageThe risk of intracardiac blood stasis and prosthetic mitral valve thrombosis should be kept in mind for patients who require a temporary mechanical circulatory support after mitral valve replacement.See Article page 206. The risk of intracardiac blood stasis and prosthetic mitral valve thrombosis should be kept in mind for patients who require a temporary mechanical circulatory support after mitral valve replacement. See Article page 206. Venoarterial ECMO (VA-ECMO) is an important circulatory support modality for postcardiotomy shock at many institutions.1Extracorporeal Life Support Organization. Membership. Available at: https://www.elso.org/Membership/CenterMap.aspx. Accessed May 24, 2020.Google Scholar Chiang and colleagues2Chiang Y.P. Milano C.A. Temporary left ventricular assist device may be safer than veno-arterial extra-corporeal membrane oxygenation for treating shock in presence of mitral prosthesis.J Thorac Cardiovasc Surg Tech. 2020; 3: 206-208Google Scholar describe a 40-year-old woman who developed thrombosis on a recently implanted mitral valve bioprosthesis while she was supported with VA-ECMO. The authors successfully removed the thrombus surgically by changing the VA-ECMO support for a central temporary left ventricular assist device (LVAD) via LV apical cannulation. This elegant strategy allowed patient recovery with subsequent discharge from the hospital. Because intracardiac thrombus is a highly morbid and challenging complication, this case study nicely illustrates the hemodynamic consequences of VA-ECMO on LV loading conditions. Compromised flow through the left side of the heart due to a severely dysfunctional ventricle while on VA-ECMO support is a potentially dangerous situation. The risk of intracardiac thrombosis is further exacerbated by the presence of prosthetic material that serves as a nidus for thrombosis. In this situation, predisposing conditions—the ingredients for arterial thrombus formation—are met, including blood stasis, inflammation and thrombosis induced by prosthetic biomaterial, and hypercoagulability imposed by the postoperative state.3Labarrere C.A. Dabiri A.E. Kassab G.S. Thrombogenic and inflammatory reactions to biomaterials in medical devices.Front Bioeng Biotechnol. 2020; 8: 123Crossref PubMed Scopus (8) Google Scholar Therapeutic anticoagulation may not be sufficient to avoid intracardiac thrombus formation.4Weber C. Deppe A.C. Sabashnikov A. Slottosch I. Kuhn E. Eghbalzadeh K. et al.Left ventricular thrombus formation in patients undergoing femoral veno-arterial extracorporeal membrane oxygenation.Perfusion. 2018; 33: 283-288Crossref PubMed Scopus (26) Google Scholar The surgical strategy chosen by the authors, a temporary centrifugal LVAD with apical cannulation, is a very efficient way to unload the left ventricle and maintain a washing flow dynamic through the mitral bioprosthesis. A large-caliber LV apical cannula is predictably efficient at unloading the left ventricle and simultaneously promoting high-volume, mostly unidirectional flow across the mitral valve from the left atrium to the left ventricle. A smaller caliber LV vent placed either through the left atrium or LV apex may not reproduce the favorable flow dynamics of a large-bore LVAD apical cannula. However, the temporary LVAD does pose higher surgical risk in the setting of postoperative myocardial stunning. Candidacy for this approach would be contingent on the tissue quality of the LV apex as well as the surgeon's familiarity with LV apical cannulation techniques. Other strategies to minimize stasis can be classified as those that decrease left ventricle preload (eg, left atrial trans-septal venting, pulmonary artery venting, or Impella device [Abiomed Inc, Danvers, Mass]), or reduce left ventricle afterload (eg, intra-aortic balloon pump). Patients at risk for left-sided chamber stasis and thrombosis during mechanical circulatory support will require an individualized treatment strategy that ranges from placement of an intra-aortic balloon pump to a temporary central LVAD, as employed here. The balance between surgical risk and benefit is dependent on the degree of ventricular dysfunction, coagulation status, mode of presentation, and level of acuity. This case highlights the need to anticipate and monitor for left ventricle distension and stasis in patients supported with VA-ECMO and possess risk factors for thrombosis such as severely depressed LV function with poor LV ejection, inconsistent or lack of aortic valve opening, presence of intracardiac prosthetic material, anticipated low anticoagulant levels due to factors such as postoperative bleeding risk, and previous thrombus in left-sided cavities. Minimizing the risk of intracardiac thrombosis by utilizing an LV venting strategy whether peripherally (trans-septal venting or Impella device) or centrally placed should be strongly considered early in these thrombosis-prone settings. The authors should be congratulated for their thoughtful efforts and success in this young patient faced with a complex shock scenario. Temporary left ventricular assist device may be safer than veno-arterial extracorporeal membrane oxygenation for treating shock in the presence of a mitral prosthesisJTCVS TechniquesVol. 3PreviewIntracardiac thrombosis (ICT) is a devastating complication of veno-arterial extracorporeal membrane oxygenation (VA ECMO).1,2 Reduced intracardiac flow due to decreased preload and increased afterload is part of the presumed mechanism. A recently implanted mitral prosthesis may exacerbate this situation. We describe mitral prosthesis thrombosis in a patient supported with VA ECMO who was successfully bridged to recovery using a temporary left ventricular assist device (LVAD) with apical inflow to maintain flow across the prosthesis. Full-Text PDF Open Access

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