1417 HYPOXIA IS INDEPENDENTLY ASSOCIATED WITH POOR OUTCOME IN UROTHELIAL BLADDER CANCER PATIENTS TREATED WITH RADICAL CYSTECTOMY
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Résumé
You have accessJournal of UrologyBladder Cancer: Invasive I1 Apr 20121417 HYPOXIA IS INDEPENDENTLY ASSOCIATED WITH POOR OUTCOME IN UROTHELIAL BLADDER CANCER PATIENTS TREATED WITH RADICAL CYSTECTOMY Peter J. Bostrom, John Thoms, Bas W.G. van Rhijn, Omer Ahmed, Oleksandr Stakhovskyi, David Margel, Andrew Evans, Tuomas Mirtti, Jenna Sykes, Melania Pintillie, Matti Laato, Michael Milosevic, Alexandre R. Zlotta, and Robert G. Bristow Peter J. BostromPeter J. Bostrom Toronto, Canada More articles by this author , John ThomsJohn Thoms Toronto, Canada More articles by this author , Bas W.G. van RhijnBas W.G. van Rhijn Toronto, Canada More articles by this author , Omer AhmedOmer Ahmed Toronto, Canada More articles by this author , Oleksandr StakhovskyiOleksandr Stakhovskyi Toronto, Canada More articles by this author , David MargelDavid Margel Toronto, Canada More articles by this author , Andrew EvansAndrew Evans Toronto, Canada More articles by this author , Tuomas MirttiTuomas Mirtti Helsinki, Finland More articles by this author , Jenna SykesJenna Sykes Toronto, Canada More articles by this author , Melania PintillieMelania Pintillie Toronto, Canada More articles by this author , Matti LaatoMatti Laato Turku, Finland More articles by this author , Michael MilosevicMichael Milosevic Toronto, Canada More articles by this author , Alexandre R. ZlottaAlexandre R. Zlotta Toronto, Canada More articles by this author , and Robert G. BristowRobert G. Bristow Toronto, Canada More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2012.02.1868AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Molecular biomarkers are urgently needed to predict individual patient outcome after radical cystectomy (RC). Intra-tumoral hypoxia has been reported to be an independent prognostic marker for disease-free and overall survival in many tumor types following radiotherapy or surgery. We therefore tested whether the expression of hypoxia-associated biomarkers was a prognostic factor in muscle-invasive bladder cancer (MIBC) treated by RC. METHODS Two cohorts of MIBC patients (clinical T2/T3N0M0) treated with RC were studied following ethics approval (University of Toronto, Canada: n=99; University of Turku, Turku, Finland: n=186). An expert GU-pathologist reviewed all slides and tissue microarrays were constructed. Using semi-quantitative immunohistochemistry, the expression of the hypoxia markers HIF-1α, GLUT-1, CA-IX, as well as the Ki-67 proliferation marker, was determined by three independent reviewers. Mean expression was used for outcome analyses. The association between each markers and disease-specific survival (DSS) were determined using univariate and multivariate analyses. RESULTS In univariate analysis (Fig 1), GLUT-1 was a significant of predictor of DSS in patients operated by RC (p=0.01). Ki-67 at a 5% cut-off was also significantly associated with DSS (p=0.028).In multivariate analysis, GLUT-1 was highly significant for predicting DSS (p=0.004) as were conventional parameters like node status or pathological stage. HIF-1α and CA-IX were not prognostic. CONCLUSIONS GLUT-1 and Ki-67 are promising biomarkers for predicting outcome in patients with MIBC treated with RC. Our results should be confirmed in large validation cohorts. Novel treatment strategies which combat tumor hypoxia should continue to be explored. © 2012 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 187Issue 4SApril 2012Page: e575 Advertisement Copyright & Permissions© 2012 by American Urological Association Education and Research, Inc.MetricsAuthor Information Peter J. Bostrom Toronto, Canada More articles by this author John Thoms Toronto, Canada More articles by this author Bas W.G. van Rhijn Toronto, Canada More articles by this author Omer Ahmed Toronto, Canada More articles by this author Oleksandr Stakhovskyi Toronto, Canada More articles by this author David Margel Toronto, Canada More articles by this author Andrew Evans Toronto, Canada More articles by this author Tuomas Mirtti Helsinki, Finland More articles by this author Jenna Sykes Toronto, Canada More articles by this author Melania Pintillie Toronto, Canada More articles by this author Matti Laato Turku, Finland More articles by this author Michael Milosevic Toronto, Canada More articles by this author Alexandre R. Zlotta Toronto, Canada More articles by this author Robert G. Bristow Toronto, Canada More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,002 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,001 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,001 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,006 | 0,001 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».