T26. VISUO-TACTILE TRANSFER AND AUDIO-VISUAL INTEGRATION IMPAIRMENT AS A NEW VULNERABILITY MARKER IN CHILDREN-AT-RISK OF SCHIZOPHRENIA, BIPOLAR DISORDER OR RECURRENT DEPRESSIVE DISORDER
Notice bibliographique
Résumé
Abstract Background Major psychiatric disorders (MPD) such as schizophrenia, bipolar disorder and recurrent major depression have shared neurodevelopmental vulnerability due to early neuronal and sensory defect as revealed by sensory and cognitive endophenotypes observed in our cohorts (e.g. Gagné et al., Schizophr. Res., 2019). There is considerable evidence that a harmonious self-development - known to be disrupted in MPDs - requires a synchronized multisensory perception and an adequate integration of sensory afferences (e.g. tactile, visual, auditory and proprio / interoception) with cognition. Early impairment in intermodal transfer (IMT) and multisensory integration (MSI) may jeopardize a stable and unified self’s and world’s representation and then would undermine self-development and represent a risk factor for MPD. IMT is the capability to transfer a percept coming exclusively from a sensory modality (e.g. tactile) to another modality (e.g. visual). MSI is the ability to integrate sensory inputs from different modalities (e.g. visual and auditory) to have a better information processing. This study shows that impairment in IMT/MSI may be a vulnerability marker in children genetically at-risk. Methods Sample: Forty-four offspring (21 girls) of patients suffering from a MPD and thus genetically at-risk for MPD (GatR) aged from 9–15 years old (mean age = 12.06) were recruited from the cohort study INTERCEPT through the HoPE program of the CIUSSS de la Capitale-Nationale. Twenty-five controls (19 girls) with no family history of MPD and no DSM-V disorder aged from 9–15 years old (mean age = 12.87) were recruited using advertisements or control bank. IMT Task: Each condition has 12 trials and the shapes are hidden from sight during palpation. MSI Task: - Simple reaction time (RT) task comprising 80 trials with unimodal stimuli (Auditory OR Visual) and 40 trials with AV (Auditory and Visual simultaneously) multimodal stimuli presented randomly. Results IMT task: When compared to controls, GatR were impaired in the three conditions (T-T: 9.77 vs. 10.32, T-V: 9.89 vs. 9.96, V-T: 9,11 vs. 9.92) with significant impairments both for T-T (t(60.53) = 2.18, p = 0.017) and V-T (t (57.28) = 2.33, p = 0.012) conditions. MSI task: GatR showed a deficit in MSI for almost all RT ranges (except for a peak at 185 ms), while control participants showed MSI facilitation for ranges from 150 to 200 ms. Discussion Developmentally genetically high-risk children would show significant impairments both in IMT and MSI that might enter into the group of indicators of brain dysfunctions, or risk endophenotypes, that both children at risk and adult patients carry (Paccalet et al., Schizophr. Res., 2016; Maziade, New Eng J Medicine, 2017). In addition, the two tasks would be valid and sensitive to the early sensory alterations in self-development. Finally, the battery is brief, user-friendly and playful for children.
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Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,001 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,000 |
| Bibliométrie | 0,000 | 0,001 |
| Études des sciences et des technologies | 0,001 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,006 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».