Risk factors and clinical features of mild cognitive impairment in patients with ischemic cerebral small vessel disease： a retrospective case series study
Notice bibliographique
Résumé
Objective To investigate the risk factors and clinical features of mild cognitive impairment （MCI） in patients with ischemic cerebral small vessel disease （SVD） for early diagnosis and prevention. Methods Montreal Cognitive Assessment Scale （MoCA） was used to screen MCI. The related risk factors and other clinical data were collected, and other neuropsychological tests were conducted. SVD was divided into leukoaralosis （LA）, lacunar infarction （LI）, and LA ＋ LI. Results A total of 143 patients with SVD were enrolled （68 in an MCI group, 75 in a non-MCI group）. Univariate analysis showed that there was no significant difference in the constituent ratio of age and gender between the MCI group and the non-MCI group, but the years of education in the MCI group was shorter than that in the non-MCI group, while the composition ratios of hypertension （69. 11% vs. 45. 33 % ;X2 = 8. 215, P = 0. 004）, diabetes （57. 35% vs. 40. 00% ; X2 = 4. 301, P = 0. 038 ）, hyperlipidemia （48. 53% vs. 24. 00% ; X2 = 9. 352, P = 0. 002 ）, carotid atherosclerosis （41.18% vs. 21.33% ;X2 =6. 592, P =0. 010）, and smoking （32. 35% vs. 14. 67% ;X2 =6. 285, P =0. 012）, as well as the levels of uric acid （351.81± 83.21 mmol/L vs. 323.03 ±80. 43 mmol/L; t = 2. 102, P = 0. 037） and total cholesterol （5.26± 1.26 mmol/L vs. 4. 56 ± 1.23 mmol/L; t = 3. 326, P = 0. 001） were significantly higher than those in the non-MCI group. Multivariate logistic regression analysis showed that hypertension （odds ratio OR] 2. 227, 95% confidence interval [ CI], 1. 001 -4. 954; P =0. 026）, diabetes （OR 2. 056, 95% CI 1. 862 -4. 937; P =0. 046）, hyperlipidemia （OR 2. 528, 95% CI 1. 361 - 5. 770; P =0. 028）, carotid atherosclerosis （OR 2. 658, 95% CI 1. 110 -6. 367; P =0. 029）, smoking （OR 2. 566, 95% CI 1. 017 - 6. 474; P = 0. 046）, and years of education （OR 0. 825, 95% CI 0. 745 - 0. 914; P = 0. 000） were the independent risk factors for the occurrence of MCI in patients with SVD. The subscores in the MCI group, includingMoCA total score （18.44 ± 5.60 vs. 27. 09 ±1.37; t= -12.422; P=0.000）, as well as visuoconstructional skills （2. 65 ± 1.39 vs. 4.49 ±0 . 74; t = - 9. 762; P = 0. 000）, attention （4.48 ± 1.70vs. 5. 89 ± 0. 31; t = 6. 706, P=0.000）,language （1.69 ± 0.80vs. 2. 41 ± 0. 95;t=4.893, P= 0.018）, abstraction （0.85 ± 0.69vs. 1.71 ± 0.53; t= -7.081, P=0.000）, delayed recall （1.29± 1.01 vs. 4. 04± 0. 99; t = 13. 824, P =0. 000） were significantly lower than those in the non-MCI group, and there were no significant differences in naming and orientation scores. In the MCI group, the subscores such as the MoCA total score in the LA＋ LI group （17.04 ±6. 15 vs. 21.04 ± 3.98; P〈 0.05）, as well as visuoconstructional skills （1.68 ± 1. 16 vs. 3.24 ± 1.13; P〈0. 05）, attention （3.92 ± 2. 03 vs. 5.19 ± 0. 87; P 〈0. 05）, delayed recall （1.35 ± 1.01 vs. 1.86 ±1.58; P 〈0. 05） were significantly lower than those in the LI group; the subscores such as the MoCA total score in the LA group （18. 18 ± 5.31 vs. 21.04 ± 3.98; 〈 =0.05）, as well as visuoconstructional skills （2.56 ±1.78 vs. 3.24 ±1.13; P〈0.05）, language （0.64 ± 0.23 vs. 1.24 ±0.83;P〈0.05）,delayedrecallO. 69 ± 0.58vs. 1.86 ±1.58;P〈0.01）were significantly lower than those in the LI group; the visuoconstmctional skills in the LA ＋ LI group was significantly lower than that in the LA group （1.68 ±1.16 vs. 2. 56 ± 1.78; P〈0. 05） and the LI group （1.68 ± 1.16 vs. 3.24± 1.13; P〈 0. 05）. Conclusions Hypertension, diabetes, hyperlipidemia, carotid atherosclerosis, smoking and the low level of education were the independent risk factors for MCI in patients with SVD. After SVD, the cognitive impairment in MCI presented as multiple cognitive domains impairments, including visuoconstructional skills and delayed recall. Cognitive impairment differed among the different types of SVD. Key words: Stroke; Brain Infarction; Cerebrovascular Disorders; Leukoaraiosis; Cognition Disorders; Neuropsychological Tests; Risk Factors
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».