The evaluation on mild cognitive dysfunction and behavior change in patients with obstructive sleep apnea hypopnea syndrome based on event related potential
Notice bibliographique
Résumé
Objective To investigate the mild cognitive impairment and behavior changes measured by neuropsychological test scale evaluation and the P300 of ERP in the patients with obstructive sleep apnea hypopnea syndrome (OSAHS).Methods A prospective study with 10 moderate to 26 severe OSAHS patients and 17 controls were carried out to determine whether the participants have mild cognitive impairment (MCI) by Montreal cognitive assessment scale (MoCA).Parallel Epworth sleepiness scale (ESS),Hamilton Anxiety Scale (HAMA),Hamilton Depression Scale (HAMD),symptom checklist 90 and P300,respectively,in patients with moderate,severe OSAHS group and normal control group to compare their cognitive function and behavior change.Correlation and multiple linear regression analysis between MoCA score,P300 parameters and the correlation with ESS score.Results In moderate to severe OSAHS patients in Cz,C3,C4,P300 latency was significantly prolonged compared with normal control group (F =4.164,4.018,3.960,P ＜0.05) ;MoCA score of severe OSAHS group (25.42±2.76) was significantly prolonged (F =3.954,P ＜0.01) than that of the normal control group (27.41±1.80).The MoCA analysis showed that memory/delayed recall score of the severe group (2.81 ± 0.98) was significantly decreased than the normal control group (4.06 ± 0.97,Z =13.075,P ＜0.01).The HAMA scores of the moderate and severe group were significantly higher than the normal group (F =3.576,P ＜0.05).The HAMD scores of the severe group were also significantly higher than the normal group (F =3.487,P ＜0.05).Correlation analysis showed that Fz,Cz,Pz,C3,C4,P300 latency and MoCA score was negatively correlated (r =-0.422,-0.410,-0.374,-0.424,-0.442,P ＜0.01) ;Fz P300 amplitude was negatively related to MoCA score (r =-0.346,P =0.013),ESS score and sleep apnea hypopnea index (AHI),the longest apnea time were positively correlated (r =0.409,0.342,P ＜ 0.05),and the average finger pulse oximetry (MSPO2) were negatively correlated (r =-0.342,P =0.041),memory/delayed recall and the minimum SPO2 (LSPO2) were positively correlated (r =0.355,P =0.041).Pz P300 latency and Fz P300 amplitude had significant influence on the MoCA.Conclusions ①Moderate to severe OSAHS patients existing MCI;②There was anxiety in moderate to severe OSAHS patients,depression in severe ones;③P300 detection can be used as electric physiological indicator of the evaluation of cognitive dysfunction in OSAHS patients,early detection of OSAHS in patients with cognitive dysfunction,combined with the MoCA score may provide the basis for early clinical intervention. Key words: Obstructive sleep apnea hypopnea syndrom; Cognitive function; Event related potential P300 ; The Montreal cognitive assessment scale; Anxiety; Depression
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Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».