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Enregistrement W3035996799

A magzatvedő vitaminok és a táplálkozás

2009· article· hu· W3035996799 sur OpenAlexaboutno aff
E Czeizel

Notice bibliographique

RevueÉlelmiszer, Táplálkozás és Marketing · 2009
Typearticle
Languehu
DomaineMedicine
ThématiqueFolate and B Vitamins Research
Établissements canadiensnon disponible
Organismes subventionnairesnon disponible
Mots-clésMethylenetetrahydrofolate reductaseMedicineVitaminInternal medicineBiologyBiochemistryGene
DOInon disponible

Résumé

récupéré en direct d'OpenAlex

Proteins get into our body in the way of nutrition go to aminoacids. Homocistein, which is an end product of an aminoacid is poison in a certain blood level (12 micromol/l). The pletoric homocistein is deposited in veinwall and – among several things because of the activation of bad cholesterol (LDL) – can cause early cerebral sclerosis, in this way its role is proven in heart-attack, strokes and perferic veindiseases. Summarising the former results of researches it is accountable for 20% of deaths due to cardiovascular diseases. If a woman with high homocistein level gets pregnant, this poison can cause anencephalia or spina bifida and other embryogeny disorders can develop in embryos. Several enzymes are responsible for detoxication of homocistein. The most important among them is MTHFR. All the enzymproteins are leaded by genedublett. Bigger part of Hungarians are not able to detoxicate homocistein, because both of MTHFR enzyme leader genedublett are inaccurate in 11% of the nation and one half of this genedublett is inaccurate in 45% of Hungarians. Researches of former years have verified that folacid (synthetic form of B11 vitamin) and three other B vitamins: B2, B3 and B12 are able to detoxicate homocistein and in this way they are able to avoid cardiovascular and other embryogeny disorders. Despite of inaccurate genedublett due to mentioned vitamins MTHFR-enzyme comes into play and forms homocistein to useful aminoacid (metionin). Therefore it is obligated in the whole USA to enrich flour with folacid from January 1, 1998. As a result of this disposal the bloodlevel of poisoning homocistein decreased by 38% among inhabitants and the folacidless anaemia left off. The occurrence of anencephalia and spina bifida is considerably (by 30%) lower. Finaly – and it is the most important in the point of public health view – that deaths caused by cardiovascular diseases are less current, 31000 strokes and 17000 heart attacks became avoidable due to this disposal. The example of the USA has been followed by Canada, Chile and other countries. The prevalence of anencaphalia and spina bifida diseases has decreased by 50%. The yearly wheat-production is 2.4 million tons in Hungary from that 1.4 million tons are consumed by inhabitants. 4-8 mills of working 150 mills are able to use the high-tech methods to enrich in vitamins. However, they are able to cover 80% of Hungarian wheat-needs. The remaining 20% could be enough for those people who do not want this opportunity of health-protecting. At the same time it would be necessary to start a big advertising campaign „of general interest” to popularize „our new everyday bread” which is not only for assuaging our hungry but protecting our health, too. Folacid alone is not so effective then the vitamin-combination, although it is much cheaper. The enrichment in folacid needs 280 million Forint, the enrichment in all of the B-vitamins needs 2.2 billion Forint every year. The budget or the leaders of millindustry could cover this amount of money. Because the wheat enriched in vitamins could be an appealing export-product for agribusiness and in this way the wheat surplus could be brought down. As an affect of enriching wheat in vitamins would decrease the number of lost people through – the leading reason of deaths – cardiovascular diseases. The optimistic calculation shows that it could mean the avoidance of ten thousand people’s death, but the most pessimistic calculations also indicate of the order of several thousands. The ratio of some kind of embryogeny diseases would also decrease which would be important for affected neonates’ families and for the society as well as it would increase the pleasure to have more children. There would be several other – more difficult to measure – beneficial healthprotecting affects, like mitigation of old age dulling (in what the role of high level of homocistein is verified) and decrease of some types of cancers (the folatdefected nutrition of Hungarian population increases the ratio of cancerous diseases).

Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.

Comment cette classification a été obtenuedéplier

Prédiction machine sur la base complète

Imitation des enseignants

Ni prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.

score de la tête « metaresearch » (Codex)0,001
score de la tête « metaresearch » (Gemma)0,001
Version: metacan-v3-hybrid-931329e0061cStatut de validation: machine_predicted_unvalidated
Catégories candidatesaucune
Catégories consensuellesaucune
DomaineSignal candidat: aucune · Signal consensuel: aucune
Devis d'étudeSignal candidat: Sans objet · Signal consensuel: aucune
GenreSignal candidat: Autre · Signal consensuel: aucune
Score de désaccord entre enseignants0,065
Score d'incertitude au seuil0,217

Scores du classifieur distillé par catégorie (deux têtes)

CatégorieCodexGemma
Métarecherche0,0010,001
Méta-épidémiologie (sens strict)0,0010,000
Méta-épidémiologie (sens large)0,0010,001
Bibliométrie0,0020,001
Études des sciences et des technologies0,0010,001
Communication savante0,0040,002
Science ouverte0,0010,002
Intégrité de la recherche0,0020,003
Charge utile insuffisante (le modèle a refusé de juger)0,0650,027

Scores machine (provisoires)

Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.

Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.

Tête enseignante Opus0,017
Tête enseignante GPT0,307
Écart entre enseignants0,290 · la distance entre les deux têtes enseignantes sur ce seul travail
Statut de validationscore_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découle

Classification

machine, non validée

Prédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.

Les modèles n’ont appliqué aucune catégorie : rien dans la taxonomie ne correspondait à ce travail.
Devis d'étudeSans objet
Domainenon disponible
GenreAutre

Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».

En bref

Citations0
Publié2009
Routes d'admission1
Résumé présentoui

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