Genetic analysis of disease resilience in wean-to-finish pigs from a natural disease challenge model
Notice bibliographique
Résumé
The objective was to estimate the genetic parameters of performance and resilience of growing pigs under disease. Data were from 3,139 Yorkshire × Landrace wean-to-finish pigs that were exposed to a natural polymicrobial disease challenge that was established by entering naturally infected animals into a nursery barn, targeting various viral and bacterial diseases. The challenge was maintained by entering batches of 60 or 75 healthy nursery pigs every 3 wk in a continuous flow system. Traits analyzed included average daily gain (ADG), feed intake (ADFI) and duration (ADFD); feed conversion ratio (FCR); residual feed intake (RFI); mortality (MOR); number of health treatments (TRT); health scores (HScore); carcass weight (CWT), back fat (CBF) and loin depth (CLD); dressing percentage (DRS); lean yield (LYLD); day-to-day variation in feed intake and duration (VARFI and VARDUR); and the proportion of off-feed days (OFFFI and OFFDUR). Analyses were performed by mixed linear models with genomic relationships. The resilience traits, such as TRT, MOR, and HScore, were lowly heritable (up to 0.15) but had high genetic correlations with each other. Performance traits, such as ADG, ADFI, ADFD, FCR, RFI, and carcass traits, were moderate to highly heritable (0.17 to 0.49). Heritabilities of resilience indicator traits such as OFF and VAR had low to moderate heritabilities (0.08 to 0.23) but were higher when based on duration vs. amount. ADFI had a low genetic correlation with ADFD (0.13). ADG in the challenge nursery had stronger negative genetic correlations with both TRT and MOR than ADG in the finisher (-0.37 to -0.74 vs. -0.15 to -0.56). ADFI and FCR had moderate negative (-0.21 to -0.39) and positive (0.34 to 0.49) genetic correlations, respectively, with TRT and MOR. ADFD and RFI had very low genetic correlations with TRT and MOR. CWT and DRS were moderately negatively correlated with TRT and MOR (-0.33 to -0.59). Resilience indicator traits based on feed intake or duration had moderate to high positive genetic correlations with TRT (0.18 to 0.81) and MOR (0.33 to 0.87). In conclusion, performance and resilience traits under a polymicrobial disease challenge are heritable and can be changed by selection. Phenotypes extracted from feed intake patterns can be used as genetic indicator traits for disease resilience. Most promising is day-to-day variation in intake duration, which had a sizeable heritability (0.23) and favorable genetic correlations with MOR (0.79) and treatment rate (0.20).
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Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,001 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».