Abstract C123: Ethnocentric differences in sarcopenic obesity and body composition in response to an aerobic and resistance exercise intervention for breast cancer survivors
Notice bibliographique
Résumé
Abstract Background and Purpose: Hispanic breast cancer survivors (HBCS) have a 1.1-1.5 greater risk of breast cancer mortality when compared to non-Hispanic breast cancer survivors (NHBCS). This disparity may result from modifiable lifestyle factors, as Hispanic women are more apt to be obese and sedentary than matched non-Hispanic counterparts, placing them at risk for obesity-related comorbidities. Also, gains in fat mass with declines in lean mass, known as sarcopenic obesity (SOb), often occur as a side effect of cancer treatment. Thus, participation in physical activity is paramount, as exercise is strongly associated with lowering the risk of cancer recurrence and premature mortality. The purpose of this analysis was to examine ethnicity as a moderator of the effects of a 16-week supervised aerobic and resistance exercise intervention on SOb and body composition (BCM) in overweight/obese breast cancer survivors. Experimental Design: Sedentary, overweight or obese (BMI>25.0 kg/m2) breast cancer survivors (Stage I-III; n=100) were randomized to exercise (n=50) or usual care (n=50). The exercise intervention promoted supervised, progressive moderate-vigorous (65-85% maximum heart rate [MHR]) aerobic and resistance exercise thrice weekly for 16 weeks. Markers of SOB and BCM, including appendicular skeletal muscle index (ASMI), BMI, % body fat and truncal fat were measured at baseline and post-intervention (4 months). Differences in mean changes for outcomes by ethnicity were evaluated using linear mixed-models to assess effect modification. Summary of Results: The study enrolled 57 HBCS and 43 NHBCS with an average age of 53.5±10.4 years and BMI of 33.5±5.5 kg/m2. HBCS were diagnosed with more advanced cancers, were significantly more obese and less physically active compared to NHBCS (p<0.001); 96% of the HBCS and 92% of the NHBCS presented with SOb. Post-intervention, SOb and BCM indices were significantly improved in the exercise arm (both HBCS and NHBCS) as compared to baseline (p 0.01) and usual care (p<0.001). However, HBCS exhibited more favorable improvements compared to NHBCS, including an increase in ASMI (mean difference, -2.1; 95% confidence interval (95% CI), 0.4 to 5.1; p<0.001) and truncal fat (-4.4; 95% CI, -9.1 to -0.8; p<0.001). Ethnicity was found to moderate the effect of the exercise intervention on fat mass (P for interaction=0.09) and % body fat (P for interaction=0.09). Conclusions: HBCS may achieve better outcomes with exercise in attenuating disparities related to SOb and BCM. To our knowledge, this is the first study to investigate ethnocentric differences between HBCS and NHBCS as they pertain to participation in physical activity and high-risk comorbidities related to poorer cancer prognosis and mortality. Exercise presents as a useful lifestyle modifiable intervention to attenuate ethnic health disparities in breast cancer survivors; future studies should aim to enroll diverse populations. Citation Format: Frank C. Sweeney, Wendy Demark-Wahnefried, Kerry S. Courneya, Debu Tripathy, Nathalie Sami, Kyuwan Lee, Thomas A. Buchanan, Darcy Spicer, Leslie Bernstein, Joanne E. Mortimer, Christina M. Dieli-Conwright. Ethnocentric differences in sarcopenic obesity and body composition in response to an aerobic and resistance exercise intervention for breast cancer survivors [abstract]. In: Proceedings of the Eleventh AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2018 Nov 2-5; New Orleans, LA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2020;29(6 Suppl):Abstract nr C123.
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Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,004 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».